Publications by authors named "Kanako Ontsuka"
Article Synopsis
- Epidermal hyperplasia is a key characteristic in both atopic dermatitis and psoriasis, and this study investigates the role of periostin, a protein previously linked to atopic dermatitis, in psoriasis-related hyperplasia.
- The study involved immunohistochemical analysis of skin biopsies from psoriasis patients and the use of periostin-deficient mice in an imiquimod-induced psoriasis model to assess periostin's role.
- Results showed that periostin is significantly expressed in psoriasis patients and is crucial for epidermal hyperplasia, but its influence occurs independently of key inflammatory pathways typically involved in psoriasis, suggesting it is a common mediator in skin inflammation across both conditions.
Article Synopsis
- Keratinocyte proliferation and differentiation are typically balanced, but this balance can be disrupted in wound healing and conditions like atopic dermatitis due to epithelial-mesenchymal interactions mediated by cytokines and growth factors.
- Periostin, a protein involved in tissue structure, plays a significant role in promoting keratinocyte hyperproliferation during atopic dermatitis and is vital for reepithelialization in wound healing.
- The study found that IL-1α from keratinocytes leads to IL-6 production from fibroblasts, and periostin is essential for this process, enhancing IL-6 levels and regulating keratinocyte behavior through a feedback mechanism linking the two proteins.
Cutaneous wound repair is a highly ordered and well-coordinated process involving various cell lineages and many molecular effectors. Cell-matrix interactions through integrin molecules provide key signals important for wound repair. Periostin is a matricellular protein that may provide signals important during tissue development and remodelling by interacting with several integrin molecules, via the phosphatidylinositol 3-kinase/Akt and MAP kinase pathways.
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