Publications by authors named "Kanako Kawakami"
Study on enteral nutrient components causing decreased gastric phenytoin absorption.
JPEN J Parenter Enteral Nutr
September 2023
Article Synopsis
- Coadministration of certain enteral nutrients (ENs) negatively impact the absorption of the antiepileptic drug phenytoin (PHT), but the underlying mechanisms remain unclear.
- Researchers used a model with Caco-2 cells to investigate how different nutrients affect the permeability of PHT, finding that casein, digested soy protein, and dextrin significantly reduced its absorption, while digested casein had the opposite effect.
- The study concludes that the composition of ENs can influence PHT absorption, which is crucial for determining the best ENs to use alongside oral PHT treatment.
Ribosomal protein L3 (RPL3) is known to be an indispensable and essential component for the peptidyltransferase center. In the present study, we found a novel function of RPL3 using a Xenopus laevis oocyte expression system. When expressed in X.
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