Publications by authors named "Kanako Ino"
Article Synopsis
- Brown adipose tissue (BAT) is crucial for burning fatty acids and has potential as a treatment for obesity and diabetes, but its effectiveness under these conditions is unclear.
- A study using diet-induced obesity C57BL/6J mice found that levels of important fatty acid oxidation enzymes and uncoupling protein 1 (Ucp1) increased significantly after a short-term high-fat diet (HFD), indicating enhanced fat-burning capacity.
- However, after long-term HFD feeding, these levels decreased, suggesting that prolonged obesity may impair BAT's ability to respond to fat, likely due to changes in mitochondrial function.
To investigate the effectiveness and safety of GVHD prophylaxis using FK506 alone as a continuous infusion, 104 patients who underwent reduced-intensity cord blood transplantation were retrospectively reviewed. The respective incidence of acute GVHD was 25 grade 1(24. 1%), 19 grade2(18.
View Article and Find Full Text PDFIn this study, we investigated the level of gut absorption following oral beclomethasone dipropionate (BDP) administration by measuring the blood concentration of its metabolites measured by LC-MS/MS using the HPLC method. Five patients who were administered BDP orally for gut GVHD were included. The blood concentrations of beclomethasone-17-monopropionate (17BMP), which is one of the active metabolites of BDP, were 618 approximately 1, 749 pg/mL in 4 of the studied 5 patients, which was comparable to that after inhalation of BDP; however, it was relatively higher in one patient (2,439+/-161 pg/mL).
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