Publications by authors named "Kanaka Valli Manyam"
The role of chromatin biology and epigenetics in disease progression is gaining increasing recognition. Genes that escape X chromosome inactivation (XCI) can impact neuroinflammation through epigenetic mechanisms. Our previous study has suggested that the X escapee genes Kdm6a and Kdm5c are involved in microglial activation after stroke in aged mice.
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- Chromatin biology and epigenetics are increasingly recognized for their roles in disease progression, particularly in neuroinflammation related to genes that escape X chromosome inactivation (XCI).
- Research indicates that specific genes involved in microglial activation after a stroke in aged mice could be modulating inflammatory responses through these epigenetic mechanisms.
- The study explores how the demethylation of histones H3K27Me3 and H3K4Me3 affects the transcription of interferon regulatory factors (IRF5 and IRF4), contributing to inflammation and worse outcomes after stroke, highlighting a critical role for IRF5 signaling in this process.
Ischemic stroke induced inflammatory responses contribute significantly to neuronal damage and stroke outcomes. CD200 ligand and its receptor, CD200R, constitute an endogenous inhibitory signaling that is being increasingly recognized in studies of neuroinflammation in various central nervous system disorders. CD200 is a type 1 membrane glycoprotein that is broadly expressed by endothelia and neurons in the brain.
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