Publications by authors named "Kana Masuda-Kuroki"

Article Synopsis
  • Psoriasis is driven by immune cell interactions, with a focus on S1PR2, which hasn’t been thoroughly explored before, despite other S1PR antagonists showing promise in treatment.
  • Using techniques like spatial transcriptomics and flow cytometry, researchers studied how S1PR2 impacts immune responses in a mouse model of psoriasis.
  • The findings indicate that S1PR2 in keratinocytes helps regulate inflammation by inhibiting Th17 cell recruitment, suggesting that activating S1PR2 might offer a new treatment strategy for psoriasis.
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Mast cells (MCs) are tissue-resident immune cells of a hematopoietic origin that play vital roles in innate and adaptive immunity. Human MCs can be isolated and differentiated from various tissue sources, including cord blood, when supplemented with cytokines such as stem cell factor, interleukin 3, and interleukin 6. Our current research study has shown significant differences in the marker expressions of human cord blood-derived mast cells (hCBMCs) based on donor dependency and the type of medium used for culturing and differentiation.

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Psoriasis is a long-lasting skin condition characterized by redness and thick silver scales on the skin's surface. It involves various skin cells, including keratinocytes, dendritic cells, T lymphocytes, and neutrophils. The treatments for psoriasis range from topical to systemic therapies, but they only alleviate the symptoms and do not provide a fundamental cure.

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Recent studies have identified a subtype of the S1P-receptor family called sphingosine-1-phosphate receptor 2 (S1PR2), which plays a crucial role in maintaining the skin barrier. It has been observed that S1PR2 and () work together to regulate the skin barrier. However, the interaction between these two factors is still unclear.

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Activation and degranulation of mast cells (MCs) is an essential aspect of innate and adaptive immunity. Skin MCs, the most exposed to the external environment, are at risk of quickly degranulating with potentially severe consequences. Here, we define how MCs assume a tolerant phenotype via crosstalk with dermal fibroblasts (dFBs) and how this phenotype reduces unnecessary inflammation when in contact with beneficial commensal bacteria.

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Sphingosine 1-phosphate (S1P) is a product of membrane sphingolipid metabolism. S1P is secreted and acts via G-protein-coupled receptors, S1PR1-5, and is involved in diverse cellular functions, including cell proliferation, immune suppression, and cardiovascular functions. Recent studies have shown that the effects of S1P signaling are extended further by coupling the different S1P receptors and their respective downstream signaling pathways.

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Background: Palmoplantar pustulosis (PPP) sometimes presents with nail lesions, which affect the patients' quality of life (QOL). However, little is known about nail lesions in PPP, and there is currently no established method for assessing them.

Objective: This study aimed to analyze the impact of PPP-related nail lesions with the patients' QOL.

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Article Synopsis
  • - Pustulotic arthro-osteitis (PAO) is a common condition linked to palmoplantar pustulosis (PPP), particularly among Japanese patients, with a study identifying PAO in 28.6% of those with PPP.
  • - The study involved 165 PAO patients, predominantly middle-aged women, with a mean age of 50.2 years and a significant number being smokers; focal infections were common, affecting various regions, especially the tonsils.
  • - Treatment for PAO typically includes nonsteroidal anti-inflammatory drugs, methotrexate, and other therapies, reflecting its complexity and the associations with infections in the chest area.
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Article Synopsis
  • Palmoplantar pustulosis (PPP) and pompholyx are chronic skin diseases affecting the palms and soles, often challenging to distinguish due to similar symptoms.
  • This study examined the histopathological differences between PPP and pompholyx in biopsy samples, developing a 4-point checklist to aid in diagnosis.
  • Findings suggested key histopathological features, like "vesicles without spongiosis" and "microabscess on the edges of vesicles," to effectively differentiate PPP from pompholyx, confirming the checklist's reliability.
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The skin microbiome influences skin pathophysiology. Palmoplantar pustulosis (PPP) is a chronic skin disease characterized by infectious-like pustules on the palms and soles. These pustules are thought to be sterile because bacterial cultures obtained from the pustules are negative.

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