Publications by authors named "Kana Fukuda"
Introduction: This study aimed to develop models for predicting total serum bilirubin by correcting errors of transcutaneous bilirubin using machine learning based on neonatal biomarkers that could affect spectrophotometric measurements of tissue bilirubin.
Methods: This retrospective study included infants born at our hospital (≥36 weeks old, ≥2,000 g) between January 2020 and December 2022. Infants without a phototherapy history were included.
The AhR, so called the dioxin receptor, is a member of the nuclear receptor superfamily. The ligand-free AhR forms a cytosolic protein complex with the molecular chaperone HSP90, co-chaperone p23, and XAP2 in the cytoplasm. Following ligand binding like 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD), the AhR translocates into the nucleus.
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- The aryl hydrocarbon receptor (AhR) interacts with the chaperone protein HSP90 in the cytoplasm, and its activation mechanism involves binding with specific ligands like TCDD and β-NF, leading to nuclear translocation.
- Studies show that the AhR retains its association with HSP90 during this process, suggesting that activated AhR may shuttle to the nucleus as part of a complex rather than independently.
- Upon reaching the nucleus, the ligand-bound AhR acts as a transcription factor, stimulating gene expression such as CYP1A1 within hours of ligand treatment.