Publications by authors named "Kan Fang"

Article Synopsis
  • * The study involved whole-exome sequencing of 476 cases to discover candidate genes, leading to the identification of variants in the KCNJ10 gene, which were found in 3.07% of patients.
  • * KCNJ10 variants were linked to milder PKD symptoms and impaired potassium channel function, impacting neuronal excitability and resulting in motor coordination issues in a mouse model, suggesting a possible genetic basis for PKD.
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Article Synopsis
  • Paroxysmal kinesigenic dyskinesia (PKD) is linked to irregularities in brain circuit activities, and this study aims to identify its neurophysiological markers using high-density electroencephalogram (hd-EEG) signals.
  • The research found that patients with PKD exhibit increased theta oscillations in various brain areas, which return to normal during remission, while non-remission patients show decreased functional connectivity in higher gamma frequency ranges.
  • The study successfully developed predictive models to identify remission states in PKD patients and highlighted the potential of hd-EEG as a clinical tool for monitoring and diagnosing the disorder.
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High interconversion energy barriers, depressive reaction kinetics of sulfur species, and sluggish Li transport inhibit the wide development of high-energy-density lithium sulfur (Li-S) batteries. Herein, differing from random mixture of selected catalysts, the composite catalyst with outer delocalized isoelectronic heterostructure (DIHC) is proposed and optimized, enhancing the catalytic efficiency for decreasing related energy barriers. As a proof-of-content, the FeCoO S composites with different degrees of sulfurization are fabricated by regulating atoms ratio between O and S.

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Introduction: Whether the coronavirus disease-2019 (COVID-19) pandemic is associated with a long-term negative impact on acute stroke care remains uncertain. This study aims to compare the timing of key aspects of stroke codes between patients before and after the COVID-19 pandemic.

Methods: This retrospective cohort study was conducted at an academic hospital in Shanghai, China and included all adult patients with acute ischemic stroke hospitalized via the emergency department (ED) stroke pathway during the 24 months since the COVID-19 outbreak (COVID-19: January 1, 2020-December 31, 2021).

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Red phosphorus/carbon (P/C) materials have been extensively studied as promising anodes for sodium-ion batteries (SIBs) owing to their high capacities and moderate working potentials. However, the low initial Coulombic efficiency (ICE) and unstable solid-electrolyte interphase (SEI) of P/C composites limit their widespread applications. In this study, we develop an effective presodiation method to compensate for the irreversible sodium loss of the S-doped P/C (P/C@S) anode and yield a thin, uniform, and NaF-rich SEI layer on the presodiated P/C@S (pNa-P/C@S) anode during cycling.

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Background: Paroxysmal kinesigenic dyskinesia (PKD) is the most common type of paroxysmal dyskinesias. Only one-third of PKD patients are attributed to proline-rich transmembrane protein 2 (PRRT2) mutations.

Objective: We aimed to explore the potential causative gene for PKD.

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Background: Neurological disorders are an economic and public health burden which requires efficient and adequate medical resources. Currently, little is known about the status of the quality of neurological care services available in China. As neurological primary care is mostly provided at the county hospital level, investigation of this geographical level is required.

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Monodispersed magnesium ferrite nanoparticles with enhanced magnetic properties were successfully fabricated by a simple solvothermal method without employing any templates, complex apparatus or techniques. The structure, morphology, composition, and magnetic properties of the products were tuned and characterized by X-ray powder diffraction, transmission electron microscopy, scanning electron microscopy and vibrating sample magnetometry. The results show that the reaction time and temperature have an important influence on the morphology, composition, structure and particle size of the synthesized MgFeO nanoparticles.

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In some circumstances, people interact with a virtual keyboard by triggering a binary switch to guide a moving cursor to target characters or items. Such switch keyboards are commonly used by patients with severely restricted motor capabilities. Typing with such systems enables patients to interact with colleagues, but it is slow and error prone.

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Glioma stem cells (GSCs) are a special subpopulation of glioma cells that are key to the sensitivity of tumors to treatments and to the possibility of tumor recurrence. Identifying new strategies that inhibit the growth of GSCs are therefore important for developing novel therapies for glioblastoma multiforme (GBM). In this study, CD133+ human glioma stem cells were isolated and cultured.

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Background: Implantable cardioverter-defibrillator leads from Riata® family (St. Jude Medical Inc., Sylmar, CA, USA) have been recently recalled by Food and Drug Administration for concerns of a unique type of "inside-out" insulation failure leading to conductor externalization.

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Atrial fibrillation (AF) commonly complicates the postoperative course after coronary artery bypass grafting (CABG). Among the general population, African Americans have been shown to have a lower prevalence of AF than European Americans. Although many factors have been identified to predict risk for postoperative AF, race has not been examined.

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