Publications by authors named "Kamsi Nwangwu"
COVID survivors frequently experience lingering neurological symptoms that resemble cancer-therapy-related cognitive impairment, a syndrome for which white matter microglial reactivity and consequent neural dysregulation is central. Here, we explored the neurobiological effects of respiratory SARS-CoV-2 infection and found white-matter-selective microglial reactivity in mice and humans. Following mild respiratory COVID in mice, persistently impaired hippocampal neurogenesis, decreased oligodendrocytes, and myelin loss were evident together with elevated CSF cytokines/chemokines including CCL11.
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- The acidic environment of lysosomes is crucial for their function, maintained by a V-type H ATPase, but requires additional pathways for ion balance.
- ClC-7, a Cl/H antiporter, is implicated in maintaining lysosomal acidity as part of a 'counterion pathway' and is influenced by the signaling lipid PI(3,5)P2.
- Research shows that reducing PI(3,5)P2 levels leads to increased lysosomal acidity mainly through effects on ClC-7, indicating its significant role in regulating lysosomal pH.