Publications by authors named "Kamrouz Kassiri"
Objective: To quantify interobserver agreement in the diagnosis and treatment of shoulder instabilities among expert North American shoulder surgeons. We hypothesized that interobserver consistency among this group will be significantly low in both diagnosis and treatment.
Design: Survey/Descriptive Epidemiology Study.
Article Synopsis
- Activated airway smooth muscle (ASM) cells can produce pro-inflammatory mediators like cytokines and chemokines, but the mechanisms behind this are not fully understood.
- The study found that human ASM cells express the high-affinity IgE receptor (Fc epsilonRI) and that this receptor's presence is also noted in bronchial smooth muscle of asthmatic patients.
- When the Fc epsilonRI is activated, it leads to calcium mobilization and the release of inflammatory cytokines (IL-4, IL-13, IL-5, and eotaxin) from ASM cells, suggesting they play a role in airway inflammation and bronchoconstriction related to allergic asthma.
RhoA and its downstream target Rho kinase regulate serum response factor (SRF)-dependent skeletal and smooth muscle gene expression. We previously reported that long-term serum deprivation reduces transcription of smooth muscle contractile apparatus encoding genes, by redistributing SRF out of the nucleus. Because serum components stimulate RhoA activity, these observations suggest the hypothesis that the RhoA/Rho kinase pathway regulates SRF-dependent smooth muscle gene transcription in part by controlling SRF subcellular localization.
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