Publications by authors named "Kamran Javidi Aghdam"
Schizophrenia is a disabling mental disorder that affects 1% of people over their lifetime. The etiology and mechanism of schizophrenia are very complex, and many genes are involved in many different signaling pathways in the etiology of this disease. According to recent studies, one of the important mechanisms altered in this disorder is the regulation of immune system and the inflammation mechanism.
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- - The study investigates the role of long non-coding RNAs (lncRNAs), specifically AC007278.3 and HOTAIR, in regulating the immune response in systemic lupus erythematosus (SLE), a type of autoimmune disease, and their potential as diagnostic biomarkers.
- - Blood samples from SLE patients and healthy controls were analyzed, revealing significant upregulation of the lncRNAs and their related protein-coding genes, TNF-α and IL18RAP, in the patients.
- - The lncRNAs showed strong correlation with the target genes and demonstrated high diagnostic potential, with values of 0.89 for AC007278.3 and 0.86 when combined with H