Interplay among distinct Ca conductances drives Ca sparks/spontaneous transient outward currents in rat cerebral arteries.

Key Points: Distinct Ca channels work in a coordinated manner to grade Ca spark/spontaneous transient outward currents (STOCs) in rat cerebral arteries. The relative contribution of each Ca channel to Ca spark/STOC production depends upon their biophysical properties and the resting membrane potential of smooth muscle. Na /Ca exchanger, but not TRP channels, can also facilitate STOC production.

Ca(V)3.2 channels and the induction of negative feedback in cerebral arteries.

Rationale: T-type (CaV3.1/CaV3.2) Ca(2+) channels are expressed in rat cerebral arterial smooth muscle.