Publications by authors named "Kamran Balighi"
Introduction: The skin is the largest organ system with many important clinical functions. Due to the increase in demand for cosmetic procedures and consequently the increase in complications from filler injections, this research aims to review the hospitalization cases involving filler complications.
Methodology: This study retrospectively and cross-sectionally reviews patient records hospitalized between the years 2016 to 2020, focusing on demographics (age, gender, residence), type of filler, type of complications, onset and duration of complications, duration of hospital stay, the person who administered the injection, and treatment outcomes.
Article Synopsis
- Pemphigus is a rare autoimmune condition causing blisters due to autoantibodies targeting desmoglein, impacting patient management by revealing gender differences in disease characteristics through a study comparing male and female patients.
- The study analyzed data from 1,218 pemphigus patients, finding that males experienced disease onset at an older age with more severe symptoms in specific body areas, while females had more mucosal manifestations, particularly in the gums.
- Overall, out of 44 examined variables, significant gender differences were noted in 9, highlighting the need for tailored and gender-specific treatment strategies for pemphigus.
Article Synopsis
- Hailey-Hailey disease (HHD) is a rare inherited skin condition that leads to blisters and significantly impacts quality of life, but it isn't life-threatening and lacks a standard treatment.
- In a study of 32 patients with HHD over 14 years at Razi Hospital, most patients were around 50 years old and half reported a family history of similar skin issues; the inguinal area was commonly affected.
- Treatment primarily involved topical steroids and antibiotics, with systemic steroids being used during flare-ups; the disease’s chronic nature presents ongoing challenges for effective management and correct diagnosis.
Introduction: Vitiligo is a common pigmentation disorder manifested by white macules and patches. It is accompanied by some autoimmune and neurological diseases. Recently, it has been suggested that multiple sclerosis (MS) is more common in vitiligo patients and that they have a higher risk of developing MS during their lifetime.
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- Pyogenic granuloma is a rapidly growing, red skin or mucosal lesion often seen in patients, which can bleed easily due to ulceration and is reported to be associated with COVID-19.
- A 52-year-old woman developed skin eruptions three weeks after her second COVID-19 vaccine dose.
- This case is noteworthy as it's the first documented instance of eruptive pyogenic granuloma following vaccination, and treatment with oral propranolol and PDL laser therapy showed effective results within six weeks.
Article Synopsis
- * The condition is characterized by itchy, blistering skin lesions, primarily affecting areas like the axilla and groin, due to IgA autoantibodies disrupting cell adhesion in the skin.
- * The study presents a case where a 50-year-old male with severe IgA pemphigus had a poor response to Dapsone but was successfully treated with an injection of the TNFa inhibitor, adalimumab.
Background: Acne scar is an inflammatory condition, which commonly occurs in patients with acne vulgaris, especially in adults. Mesogels have been reported effective in improving atrophic acne scars.
Aims: We investigated the efficacy of adding Profhilo (a hyaluronic acid-based filler) to subcision as a new treatment method.
Article Synopsis
- Acanthosis nigricans is a skin disorder causing dark, velvety patches, mainly in the neck and armpits, often linked to obesity and insulin resistance; it raises cosmetic concerns prompting treatment.
- This study compared the effectiveness and side effects of two treatments: tretinoin 0.05% used every other night and glycolic acid 70% applied bi-weekly for 8 weeks, focusing on neck and axillary lesions.
- Results showed tretinoin was significantly more effective for axillary lesions, enhancing treatment response and patient satisfaction, while neither treatment effectively addressed neck lesions.
Background: Evidence on the association between following healthy eating and the severity of pemphigus vulgaris (PV) is scarce. Therefore, the aim of this cross-sectional study aimed to investigate the relationship between adherence to the alternative healthy eating index (AHEI) and the severity of Pemphigus vulgaris disease in adults.
Methods: In this hospital-based cross-sectional study, a total of 138 pemphigus vulgaris cases were studied, of which 108 had pemphigus disease area index (PDAI) ≤15, and 30 had PDAI>15.
Article Synopsis
- Increased awareness of cutaneous leishmaniasis (CL) is essential in endemic areas, as it can resemble other skin conditions and may lead to serious complications.
- Two cases of chronic leishmaniasis that were misdiagnosed for years highlight the importance of early identification and treatment.
- Clinicians should strongly suspect leishmaniasis in patients with infiltrated lesions and start treatment without waiting for definitive lab tests to prevent disfigurement and secondary cancers.
Key Clinical Message: The immunosuppressant agents should be considered earlier in the course of treatment with rituximab, possibly after the unfavorable response at first cycle of treatment, especially in male patients and those with high BMI.
Abstract: Rituximab (RTX) has recently been proposed as an alternative first-line therapy for pemphigus patients. However, there are some rare reports of worsening of pemphigus following RTX therapy in the literature.
Background: Pemphigus is a group of rare but serious autoimmune blistering disorders, affecting skin and mucus membrane. Different reports have been published in respect to the coexistence of pemphigus with neoplasms, especially lympho-proliferative ones.
Case: Here, we have reported a patient previously diagnosed with pemphigus vulgaris (PV) who developed esophageal squamous cell carcinoma (SCC).
Background: The COVID-19 pandemic has raised some concerns regarding the management of chronic skin diseases, especially in patients on immunosuppressive therapy including patients with pemphigus vulgaris (PV). Literature review reveals conflicting results about the effect of monoclonal antibodies such as rituximab on clinical outcome of COVID-19.
Objectives: To assess the reciprocal interaction of COVID-19 and pemphigus and the effect of rituximab on prognosis of COVID-19 in patients.
Evaluation and monitoring of pemphigus vulgaris (PV) typically involve autoantibody detection by enzyme-linked immunosorbent assay (ELISA) and indirect immunofluorescence (IIF). We aimed to determine the levels of antipemphigus immunoglobulin (Ig) G autoantibodies using ELISA and IIF (as standard biomarkers), and compare it to prolactin, macrophage migration inhibitory factor (MIF), and C-reactive protein (CRP) (as nonstandard biomarkers) to determine which of these non-standard biomarkers is appropriate for PV monitoring. The experiment was performed before and during therapy.
View Article and Find Full Text PDFBackground: The SARS-Cov-2 pandemic has caused dermatologists around the world to adapt their practice in the aim of protecting patients with special clinical conditions such as those having skin cancers or premalignant conditions and some diagnostic or therapeutic programs would be suspended due to being infected to SARS-CoV-2. We focused the existing data in this regard through searching on PubMed, Google Scholar, and Scopus and tried to summarize recommendations for treating this group of patients in COVID era to provide a practical guide for clinicians.
Recent Findings: The number of diagnosed skin cancers dropped significantly since the beginning of the pandemic, specially in the peaks of various variants of the SARS-CoV-2 infection.
Background: For decades, the notion that elective surgeries and cutaneous procedures should be postponed for 6-12 months in patients on, or recently administered with isotretinoin, has been widely accepted. However, some recent studies showed the need for a change in this regard.
Method: Here, we reviewed the existing data in this regard through searching on PubMed, Google Scholar, and Scopus.
Article Synopsis
- Generalized pustular psoriasis is a serious skin condition that can be triggered by different factors.
- Previous research indicates a small chance of flare-ups after receiving COVID-19 vaccines.
- This report presents a unique case where a patient experienced pustular psoriasis flare-ups after both doses of the BBIBP-CorV (Sinopharm) vaccine, even while being treated with adalimumab.