Deletion of 17p in cancers: Guilt by (p53) association.

Monoallelic deletion of the short arm of chromosome 17 (del17p) is a recurrent abnormality in cancers with poor outcomes. Best studied in relation to haematological malignancies, associated functional outcomes are attributed mainly to loss and/or dysfunction of TP53, which is located at 17p13.1, but the wider impact of deletion of other genes located on 17p is poorly understood.

Mushroom DNA barcoding project: Sequencing a segment of the 28S rRNA gene.

DNA barcoding is an important molecular methodology for species identification that was developed over the last two decades and it should be covered in the biology bachelor curriculum. Here, we present an example of DNA barcoding by sequencing a segment of the 28S nuclear ribosomal large subunit rRNA gene of wild mushrooms and framing the education in a project form for undergraduate students in biology. Students perform this project in 6-8 weeks, which also includes preparing a poster, writing a report and presenting a paper related to the work in a journal club format.

Early discharge of premature infants < 37 weeks gestational age with nasogastric tube feeding: the new standard of care?

Most premature infants are hospitalised until they no longer need monitoring of vital parameters and are independent of nasogastric tube feeding (NTF). Hospital admission time easily reaches a length of multiple months in extremely preterm infants, but also in late preterms, in whom drinking may be the only problem, hospital admission time can reach weeks. This is a very stressful time for both parents and child.

A low-grade astrocytoma in a sixteen-year-old boy with a 7q11.22 deletion.

We report a patient with developmental delay due to germline AUTS2 mutation who developed a low-grade astrocytoma. While the contribution of this mutation to the pathogenesis of the tumor is not known at this time, a role of AUTS2 in deregulation of PRC1 can be a part in tumorigenesis of a brain tumor.

Mandibular overdentures retained by two implants: 10-year results from a crossover clinical trial comparing ball-socket and bar-clip attachments.

Purpose: The aim of this study was to evaluate patient satisfaction and clinical and prosthetic outcomes of two-implant mandibular overdenture treatment with different attachment types after 10 years of function.

Materials And Methods: In a crossover clinical trial, 18 edentulous subjects with complaints regarding their mandibular dentures received two implants and a new denture with magnet, ball-socket, or bar-clip attachments that were applied in a random order. At the end of the experiment, the attachment type of their choosing was fitted in the overdenture.

Mandibular implant-supported overdentures and oral function.

Objectives: Oral rehabilitation by means of implant-retained mandibular overdentures is known to improve oral function. The aim of this study was to evaluate the long-term effects of mandibular implant treatment on oral function. We quantified maximum bite force and masticatory performance 10 years after implant treatment.

[Patient satisfaction with different types of implant-retained overdentures in the edentate mandible].

The purpose of this study was to determine patient satisfaction with implant supported mandibular overdentures using magnet, bar-clip and ball-socket attachments, and to assess the relation between maximum bite force and patient satisfaction. In a crossover clinical trial, 18 edentulous patients with lower denture complaints received 2 mandibular implants and new lower and upper dentures. The lower denture initially came without any kind of attachment system, but was fitted with one of the attachment types after 3 months.

Masticatory function with mandibular implant-supported overdentures fitted with different attachment types.

Oral Rehabilitation by means of implant-retained mandibular overdentures is known to improve the oral function. The improvement may depend on the degree of retention and stability of the denture and thus on the type of attachment. In this within-patient cross-over clinical trial, we examined the hypothesis that more retention and stability of the overdenture improves the masticatory function.

The effect of maximum bite force on marginal bone loss in mandibular overdenture treatment: an in vivo study.

The impact of bite force on the marginal bone response around implants is a subject of debate. This study focused on the effect of maximum bite force on marginal bone levels in mandibular implant overdenture treatment. In addition, the effect of the sequence of 3 different loading conditions on marginal bone loss was evaluated in vivo.

Patient satisfaction and preference with magnet, bar-clip, and ball-socket retained mandibular implant overdentures: a cross-over clinical trial.

Purpose: The purposes of this study were to: (1) determine patient satisfaction with implant-supported mandibular overdentures using magnet, bar-clip, and ball-socket attachments; and (2) assess the relation between maximum bite force and patient satisfaction.

Materials And Methods: In a cross-over clinical trial, 18 edentulous patients with mandibular denture complaints received two mandibular implants and new mandibular and maxillary dentures. The mandibular denture was initially without any kind of attachment system, but it was fitted with one of the attachment types after 3 months.

Masticatory function with implant-supported overdentures.

The type of attachment that is used in implant-supported mandibular overdentures may influence the retention and stability of the prosthesis and, thus, masticatory function. In this within-subject cross-over clinical trial, we examined the hypothesis that greater retention and stability of the overdenture improve the masticatory function. Eighteen edentulous subjects received 2 oral implants, a new overdenture, and, successively, 3 different suprastructure modalities: magnet, ball, and bar-clip.

Retention and postinsertion maintenance of bar-clip, ball and magnet attachments in mandibular implant overdenture treatment: an in vivo comparison after 3 months of function.

It could be hypothesised that attachments, which provide more retention against vertical and horizontal dislodgement, will be associated with more favourable parameters of oral function. This in vivo study is designed to provide data regarding initial retention force, loss of retention force after 3 months of function and postinsertion maintenance and complications associated with the use of magnet, bar-clip and ball attachments in mandibular overdenture treatment. Eighteen edentulous subjects received two permucosal implants in the inter-foramina region of the mandible, a new denture and three successive suprastructure modalities (magnet-, bar-clip and ball attachments).

The influence of various attachment types in mandibular implant-retained overdentures on maximum bite force and EMG.

The type of attachment that is used in oral rehabilitation by means of implant-retained mandibular overdentures may influence the retention and the stability of the denture. In this study, we examined the hypothesis that a better retention and stability of the denture improve the oral function. Eighteen edentulous subjects received 2 permucosal implants, a new denture, and, successively, 3 suprastructure modalities.

The use of the transmandibular implant system in extreme atrophy of the mandible; a retrospective study of the results in two different hospital situations.

This retrospective study aims to investigate and compare the results obtained with the transmandibular implant (TMI) in two different hospital situations. Group I were patients treated in a teaching hospital since 1984 by a varying group of surgeons and prosthodontists with a varying degree of experience with the TMI. Group II were patients treated in 1993 and 1994 by experienced surgeons and prosthodontists in the hospital where the TMI was originally developed.

The effect of an occlusal stabilization splint and the mode of visual feedback on the activity balance between jaw-elevator muscles during isometric contraction.

The aim of the present study was to gain an insight into the influence of a vertical bite-rise (clenching in intercuspal occlusion vs. clenching on an occlusal stabilization splint), the mode of visual feedback (VF; obtained from the compound masseter signal, from the compound anterior temporalis signal, or from the compound signal of both masseter and anterior temporalis muscles) and the EMG clenching level (10% MVC and 50% MVC) on the muscle balance between the masseter and the anterior temporalis muscles. The muscle balance was quantified as the logarithmic value of the ratio between the summated mean rectified EMG activity of the masseter muscles and this activity of the anterior temporalis muscles.

[Trichinella spiralis as a teacher or the parasite-host relationship between a threadworm and an institute].

The present paper provides a review of activities of the National Institute of Public Health in the field of studies on Trichinella spiralis in man and animals. The development of a system of (immune) surveillance of infections due to Trichinella in pigs has been central since the early sixties. Both the fluorescent antibody technique introduced in 1967 and the enzyme-linked immunosorbent assay (ELISA) published in 1974 are examples of these efforts.