Publications by authors named "Kamonthip Pakaew"
Lactobacillus reuteri TISTR 2736 alleviates type 2 diabetes in rats via the hepatic IRS1/PI3K/AKT signaling pathway by mitigating oxidative stress and inflammatory mediators.
Kamonthip Pakaew Pennapa Chonpathompikunlert Navinee Wongmanee Worarat Rojanaverawong Jaruwan Sitdhipol
Eur J Nutr
November 2024
Purpose: This study investigated the beneficial effects of Lactobacillus reuteri TISTR 2736 on glucose homeostasis, carbohydrate metabolism, and the underlying mechanisms of its actions in type 2 diabetic (T2D) rats.
Methods: A rat model of T2D was established by a combination of a high-fat diet and streptozotocin. The diabetic rats were treated daily with L.
Article Synopsis
- This study explored how the probiotic Bifidobacterium animalis TISTR 2591 affects blood glucose levels in a rat model of type 2 diabetes.
- After 4 weeks of treatment, rats showed significant improvements in fasting blood glucose, glucose tolerance, and insulin levels, along with reduced pancreatic and liver damage.
- The probiotic led to decreased liver fat accumulation and inflammation, enhancing antioxidant activity and improving overall glucose metabolism in the diabetic rats.