Room temperature HFIP/Ag-promoted palladium-catalyzed C-H functionalization of benzothiazole with iodoarenes.

A versatile synthetic protocol involving the room temperature direct arylation of benzothiazole with a wide variety of iodoarenes under Ag-promoted Pd-catalyzed conditions in HFIP as the reaction solvent has been presented. A sequential HFIP-promoted selective iodination of arenes followed by Pd-catalyzed direct arylation of benzothiazole has also been disclosed. The utility of the developed protocol has been demonstrated by the synthesis of anti-tumor agents, PMX-610 and CJM-126 (precursor).

Carbon dioxide based methodologies for the synthesis of fine chemicals.

Rapid environmental changes triggered by the increase in the concentration of heat-absorbing gases such as CO2 in the atmosphere have become a major cause of concern. One of the ways to counter this growing threat will be to efficiently convert atmospheric CO2 into value-added products via the development of efficient transition-metal-catalyzed processes. Conversion of CO2 into bulk products such as CH3OH and methane as well as its incorporation into commercial polyurethane synthesis has been achieved and reviewed extensively.

HFIP Promoted Low-Temperature SAr of Chloroheteroarenes Using Thiols and Amines.

A highly efficient and an unprecedented hexafluoro-2-propanol, promoting low-temperature aromatic nucleophilic substitutions of chloroheteroarenes, has been performed using thiols and (secondary) amines under base-free and metal-free conditions. The developed protocol also provides excellent regio-control for the selective functionalization of dichloroheteroarenes, while the utility of the protocol was demonstrated by the modification of a commercially available drug ceritinib.

Hetero-bimetallic cooperative catalysis for the synthesis of heteroarenes.

Multi-metallic cooperative catalysis has gained a lot of interest in organic synthesis over the past few years exploring various organic transformations. Of all the myriad chemical transformations, multi-metallic cooperative catalysis offers exceptional chemo-, stereo- and regio-selectivities. In recent years, hetero-multi-metallic catalysis has not only been used to synthesise only simpler organic molecules but rather more complex molecules like heteroarenes which include a variety of commercially important molecules.

Metal-Free Dehomologative Oxidation of Arylacetic Acids for the Synthesis of Aryl Carboxylic Acids.

A novel I-promoted direct conversion of arylacetic acids into aryl carboxylic acids under metal-free conditions has been described. This remarkable transformation involves decarboxylation followed by an oxidation reaction enabled just by using DMSO as the solvent as well as an oxidant. Notably, aryl carboxylic acids are isolated by simple filtration technique and obtained in good to excellent yields.