Synthesis, biological evaluation, and molecular docking of novel 1,3,4-substituted-thiadiazole derivatives as potential anticancer agent.

In an attempt to develop potent anti-cancer agents, a new 1,3,4-substituted-thiadiazole derivatives (8b-g), starting from 4-substituted-thiazol-2-chloroacetamides (4b-g), were synthesized and evaluated for their cytotoxic effects on multiple human cancer cell lines, including the hepatocellular carcinoma (HEPG-2), human lung carcinoma (A549), human breast carcinoma (MCF-7) and pseudo-normal human embryonic liver (L02) cancer cell lines by an MTT assay. Among all synthesized compounds, compound 8d showed the potent anti-cancer activities with GI values of 2.98, 2.

Synthesis, Biological and Molecular Docking Studies of Thiazole-Thiadiazole derivatives as potential Anti-Tuberculosis Agents.

Tuberculosis remains a global health threat, with increasing infection rates and mortality despite existing anti-TB drugs. The present work focuses on the research findings regarding the development and evaluation of thiadiazole-linked thiazole derivatives as potential anti-tuberculosis agents. We present the synthesis data and confirm the compound structures using spectroscopic techniques.

Assessment of Prevalence of Hypertension and its Risk Factors among Adult Tribal Population Residing in Lohandiguda Block of Bastar District of Chhattisgarh.

Background: Hypertension is known as the silent killer. It comprehends the top rank in non-infectious disease amongst adults; accountable for the deaths every year across the world. It is essential to consider the individual impact of risk factors and their impact on hypertension.

High Thoracic Epidural Anesthesia and Dexmedetomidine for Awake Off-Pump Coronary Artery Bypass Grafting: A Feasible Option for Patients with Severe Pulmonary Disease.

High thoracic epidural anesthesia in cardiac surgery as the sole anesthetic technique is used in a select groups of patients having severe pulmonary co morbidities. We describe a case series of three patients at high risk for post operative pulmonary complications where this technique was used along with dexmedetomidine infusion for conscious sedation in off pump coronary artery bypass grafting. Proper selection of patients, proper placement of the epidural catheter at the appropriate level and timing of catheter insertion and removal are of paramount importance.

Air quality assessment in the central Indian State of Chhattisgarh.

Background: Era's one of the utmost scourges is air pollution, owing to not only its impact on climate change but also its impact on public and individual's health due to combined morbidity and mortality.

Objectives: The current study was intended to monitor the air quality data from two districts of Chhattisgarh, namely Raipur and Korba, so that policymakers will be able to take corrective measures to control individual's health-related issues associated with polluted air.

Methods: All air samples were collected from around Raipur and Korba city of Chhattisgarh and submitted to the Chester LabNet, a laboratory based in 3 Oregon, USA, for analysis.

Lipoma Arborescens: A rare cause of knee swelling.

Introduction: Lipoma Arborescens is a chronic, slow growing intra articular lesion of benign nature which is commonly seen in the supra patellar region of the knee joint. It is characterised by villous proliferation of the synovium, with the replacement of the subsynovial connective tissue with fat cells. It is not a neoplasm but non-specific reactive response to chronic synovial irritation, due to mechanical or inflammatory insults.

The Outcome of Pregnancy Among Tobacco Users in Tertiary Care Hospital of Chhattisgarh Province of India.

Background: Tobacco use is responsible for numerous adverse pregnancy outcomes for females and their infants. The aim of this study was to explore the adverse outcome of tobacco use among pregnant females.

Method:  A cross-sectional study was conducted on 1250 females in the third trimester of pregnancy from April to June 2022, which were exposed to tobacco use in the form of gudaku, tobacco chewing, gutka, or smoking.

Role of Fluorescence Imaging Device in Screening of Oral Cancer: A Cross-Sectional Study in Chhattisgarh Population.

Background: Oral squamous cell carcinoma is a major health issue worldwide. Screening and early diagnosis are the key elements for the better prognosis of potentially malignant oral disorders.

Objectives: This study establishes the effectiveness of fluorescence imaging device in the early detection and precise examination of the normal-appearing oral mucosa of tobacco chewer patients in white light and fluorescence light.

Access and availability of essential medicines in Chhattisgarh: Situation in public health facilities.

Background: In 2013, the Government of Chhattisgarh announced a policy guaranteeing access to free generic medicines in all the public health facilities. This study was conducted with the objectives of evaluating the prescribing patterns of physicians in public health facilities with regard to generic medicines, and whether the prescribed generic medicines were made available to patients.

Materials And Methods: This cross-sectional study was conducting from December 2013-October 2014, using exit interviews of patients.

Assessment of Under Nutrition Using Composite Index of Anthropometric Failure (CIAF) amongst Toddlers Residing in Urban Slums of Raipur City, Chhattisgarh, India.

Introduction: Several indicators have been used for measurement of under nutrition in the past. They are overlapping and none individually provide a comprehensive number of under nourished in the community. The effort has been to discuss the use of an alternative indicator of malnutrition - the composite index of anthropometric failure (CIAF).

Location and vocation: why some government doctors stay on in rural Chhattisgarh, India.

We conducted a qualitative research study in Chhattisgarh State, India, to explore why some qualified medical practitioners decide to stay on in government rural service. The fieldwork consisted of in-depth interviews with 37 practitioners who had an established record of rural service, and data were analyzed using the 'framework' approach for applied policy research. Study participants cited complexes of reasons for staying on, including geographical and ethnic (tribal) affinities, rural upbringing, availability of schools, personal values of service, professional interests, co-location with spouses, and relations with co-workers.

Which doctor for primary health care? Quality of care and non-physician clinicians in India.

The scarcity of rural physicians in India has resulted in non-physician clinicians (NPC) serving at primary health centers (PHC). This study examines the clinical competence of NPCs and physicians serving at PHCs to treat a range of medical conditions. The study is set in Chhattisgarh state, where physicians (medical officers) and NPCs: Rural Medical Assistants (RMA), and Indian system of medicine physicians (AYUSH Medical Officers) serve at PHCs.

Early Infant Diagnosis: A New Tool of HIV Diagnosis in Children.

Background: Standard assay has limited utility in diagnosing HIV reactivity among infants till the age of 18 months by which time, many HIV-infected infants expire. The test for diagnosing infant and children below 18 months is DNA polymerase chain reaction (DNAPCR) either by dried blood spot (DBS) or whole blood sample (WBS). Early infant diagnosis (EID) project is implemented in 18 districts of Gujarat through 33 PPTCT centers from 1st April 2010.

National Rural Health Mission--hopes and fears. Concerns about targeted sterilisation, retreat of the state and privatisation.

The National Rural Health Mission (NRHM), launched by the present government as part of its honouring the Common Minimum Programme (CMP) commitment, had its content shaped by an active process of dialogue between many stakeholders. This article traces the contours of the discussions on three key concerns of civil society that influenced their contributions to the shaping of the National Rural Health Mission agenda. These three concerns were promotion of targeted sterilisation, a retreat of the state from its commitments to the health sector and that the NRHM agenda would lead to privatisation of public health facilities.

Using a diode laser to uncover dental implants in second-stage surgery.

A soft tissue diode laser offers an alternative technique for uncovering dental implants. This article presents two cases in which four dental implants were uncovered using a soft tissue laser. This technique provides an efficient and patient-friendly method to perform second-stage implant surgery, safely allowing a faster rehabilitative phase.

A Primary Dead-Weight Tester for Pressures (0.05-1.0) MPa.

Recent advances in technology on two fronts, 1) the fabrication of large-diameter pistons and cylinders with good geometry, and 2) the ability to measure the dimensions of these components with high accuracy, have allowed dead-weight testers at the National Institute of Standards and Technology (NIST) to generate pressures that approach total relative uncertainties previously obtained only by manometers. This paper describes a 35 mm diameter piston/cylinder assembly (known within NIST as PG-39) that serves as a pressure standard in which both the piston and the cylinder have been accurately dimensioned by Physikalisch Technische Bundesanstalt (PTB). Both artifacts (piston and cylinder) appeared to be round within ±30 nm and straight within ±100 nm over a substantial fraction of their heights.

A Double-Primary Dead-Weight Tester for Pressures (35-175) kPa in Gage Mode.

Primary pressure standards in the atmospheric pressure range are often established using mercury manometers. Less frequently, controlled-clearance dead-weight testers in which one component (normally the piston) has been dimensionally measured have also been used. Recent advances in technology on two fronts i) the fabrication of large-diameter pistons and cylinders with good geometry; and ii) the ability to measure the dimensions of these components, have allowed some dead-weight testers at NIST to approach total relative uncertainties (k = 2) in dimensionally-derived effective areas near 5 × 10(-6).

An Intercomparison Between NPL (India) and NIST (USA) Pressure Standards in the Hydraulic Pressure Region up to 26 MPa.

Results are presented of an intercomparison of pressure measurements between the National Physical Laboratory (NPL), India, and the National Institute of Standards and Technology (NIST), USA, using piston gauge pressure standards over the range 6 MPa to 26 MPa. The intercomparison, using the NPL piston gauge pressure standard, with a nominal effective area of 8.4×10 m and the piston gauge pressure standard, with a nominal effective area of 2.