Publications by authors named "Kamlesh Chaudhary"
Article Synopsis
- Sleep deprivation has significant negative effects on both physical and mental health, disrupting the gut-brain axis and leading to imbalances in gut microbiota.
- This imbalance, known as dysbiosis, can worsen neurological disorders such as depression, anxiety, and cognitive decline through various mechanisms like increased neuroinflammation and compromised gut barriers.
- There is growing interest in therapeutic approaches like probiotics, dietary changes, and personalized interventions to restore gut health and alleviate sleep-related neurological issues, highlighting the need for further research in this area.
The complex pathophysiology of Alzheimer's disease (AD) poses challenges for the development of therapies. Recently, neuroinflammation has been identified as a key pathogenic mechanism underlying AD, while inflammation has emerged as a possible target for the management and prevention of AD. Several prior studies have demonstrated that medications modulating neuroinflammation might lessen AD symptoms, mostly by controlling neuroinflammatory signaling pathways such as the NF-κB, MAPK, NLRP3, etc, and their respective signaling cascade.
View Article and Find Full Text PDF