Agent-Based Simulation of the COVID-19 Epidemic in Russia.

The COVID-19 pandemic has created a public health emergency in Russia and across the world. The wavelike spread of the new coronavirus infection, caused by newly emerging variants of the coronavirus, has led to a high incidence rate in all subjects of the Russian Federation. It is becoming extremely topical to get the opportunity to manage the development of the epidemic and assess the impact of certain regulatory measures on this process.

[Alirinomycin C--a novel macrolide antibiotic from Streptomyces felleus VIZR 8].

The culture of Streptomyces felleus VIZP 8 producing new macrolide antibiotic alirinomycin C was isolated in the screening of new insecticide substances. Antibiotic was related to the carbomycin-cirramycin group. Physico-chemical and biological properties investigation and identification were performed in comparison with other antibiotics of the same group, described in literature.

[Liver function at the stage of intensive tuberculosis treatment of patients with diabetes mellitus].

Intensive pulmonary tuberculosis treatment was performed in 65 patients with this disease concurrent with diabetes according to the WHO recommendations. Among them there were 44 new cases and 21 cases with relapse. Comparing the hepatic functional parameters before the first intensive stage of treatment and after its termination (following 2-3 months) showed a regular and statistically significant increase in the activity of aminotransferases and a clear tendency for increases in the values of total bilirubin and thymol tests.

[The use of non-Euclidean metrics in epidemiological classifications].

A non-Euclidean metric, stable to pollutions in sample data, for hierarchical cluster analysis in epidemiology is proposed. The simplicity of calculations permits its easy use in practice. On the basis of this metric the towns of Tula Province have been grouped according to morbidity rates in the shigellosis of Flexner and Sonne with the conjugated value of parameters.

[Validity of epidemiological classification: construction of a discriminant criterion].

A new criterion has been proposed to assess the validity of group division differences obtained by preliminary cluster analysis. The method was used to provide evidence for the validity of differences between the groups as to epidemiological classifications. The paper shows it expedient to use the method in the epidemiological analysis.

[The structure of populations of the causative agents of infectious diseases and the mechanism of the development of the epidemic process].

The parameters of clonality and preservation capacity, characterizing the population structure of the causative agents of infectious diseases, have been worked out on the basis of the clonal concept and the concept of self-restructuring of microbial populations. Different correlations between these parameters determine the existence of 9 independent groups of infections. The mechanisms and manifestations of the epidemic process of these infections have been described and the priority directions of anti-epidemic measures formulated.

[The plasmid heterogeneity of Shigella sonnei phase-I and -II strains].

The plasmid composition of S. sonnei standard strains has been studied by the method of electron microscopy of the preparations of plasmid DNA. In S.

[Dissociation and ultrastructure of the cells of Shigella sonnei isolated from gnotobiotes and obtained in vitro].

The dissociation variants of S. sonnei in phase I, isolated from germ-free rats and obtained in vitro, have been studied. Such dissociation variants have been found to form colonies with classical and atypical morphology.

[Fast and slow genome rearrangements: molecular and genetic mechanisms of changes in virulence].

Different mechanisms of virulence changes at the molecular and populational levels are discussed. The methodology and mechanisms of Streptococcus pyogenes variability are analysed. The views of the adaptive role played by insertion sequences are developed, and the design of an epidemiologico-genetic experiment is proposed, which consists in obtaining highly virulent insertion mutants and testing their properties.

[Controllable infections and the self-regulation of parasitic systems].

The control of the epidemic process is based on the knowledge of the mechanisms of self-regulation, developed in the process of evolution, in the relationship of the host and parasite populations under the changing conditions of the social and natural environment. The problem of the global and regional liquidation of infections controllable by means of immunoprophylactic measures is considered.

[Phenomenology and molecular mechanisms of Shigella sonnei dissociation: its variability in model in vivo and in vitro systems].

The dynamics of the accumulation of phase II S. sonnei in the infectious process in germ-free rats, during cultivation and in subcultures was studied. The in vivo variability of S.