Recent Advances and Future Directions in Sonodynamic Therapy for Cancer Treatment.

Deep-tissue solid cancer treatment has a poor prognosis, resulting in a very low 5-year patient survival rate. The primary challenges facing solid tumor therapies are accessibility, incomplete surgical removal of tumor tissue, the resistance of the hypoxic and heterogeneous tumor microenvironment to chemotherapy and radiation, and suffering caused by off-target toxicities. Here, sonodynamic therapy (SDT) is an evolving therapeutic approach that uses low-intensity ultrasound to target deep-tissue solid tumors.

Double Burden of Malnutrition Among Pregnant Women in Rural Jharkhand: Evidence From a Cross-Sectional Study.

Introduction: The nutritional status of pregnant women is a very important aspect of maternal and antenatal care, as malnutrition is detrimental to both the mother and the foetus. This study tries to assess the scale of the double burden of malnutrition in a rural setting in India.

Methods: A cross-sectional study was conducted on 337 pregnant women to assess the nutritional status of pregnant women using Body Mass Index and dietary intake.

Protected or not? Hepatitis B vaccination status among healthcare workers and the level of protection post-vaccination.

Background: Hepatitis B virus infection is one of the major concerns in global health care. With a far-reaching health, social, economic impact, preventive strategies form the cornerstone of its management. Knowledge about vaccination status and protection rendered thereof would aid in more wholesome management among highrisk population groups like healthcare workers.

Amelioration of cognition by hesperidin-conjugated cobalt oxide nanoparticles.

Diabetes mellitus is one of the metabolic syndromes that is associated with cognitive deficit, dementia, and Alzheimer's disease (AD) like pathology due to impaired insulin-signalling in the brain, oxidative stress and mitochondrial dysfunction. Nanotechnology is one of the most promising techniques for targeting the brain. However, the toxicity of metal nanoparticles is one of the biggest challenges to be studied.

Synthetic MRI derived relaxometry parameters: a new insight into characterization of ring enhancing lesions of brain.

Background And Purpose: Synthetic MRI utilizes the quantitative relaxometry parameters to generate multiple contrast images through a single acquisition. We tried to explore the utility of synthetic MRI derived relaxometry parameters in evaluation of ring enhancing lesions of brain.

Materials And Methods: This was a prospective study.

Transforming growth factor beta receptor type I (TGF-βRI) kinase inhibitors IOA-359 and IOA-360 stimulate erythropoiesis in MDS.

Overactivation of the Transforming Growth Factor Beta (TGF-β) pathway is implicated in the pathogenesis of cytopenias in Myelodysplastic syndromes (MDS) and Acute Myeloid Leukemia (AML). IOA-359 and IOA-360 are potent small molecule inhibitors of the TGF-beta Receptor type I kinase (TGF-βRI, also referred to as ALK5, activin receptor-like kinase 5) that abrogate SMAD phosphorylation in hematopoietic cell lines. Both inhibitors were able to inhibit TGF-β mediated gene transcription at specific doses.

Unveiling predictors of developmental delay among under-fives: Insights from a community study.

Introduction: The development of a child is a crucial factor that ultimately affects the quality of life of children. Developmental delay can be prevented if it is identified early and adequate attention is given from the start.

Methodology: A cross-sectional analytical study was conducted between December and November 2022 on 450 children by multistage cluster sampling in the Ormanjhi block of Ranchi, Jharkhand.

Maternal and child health services during COVID-19 in India: Highlighting the role of primary care physicians in maintaining continuum of care.

Background: This study aims to address the lack of substantial evidence regarding the effect of COVID-19 on maternal and child health (MCH) services in India and also highlight the role of primary care physicians in maintaining essential services during a pandemic. While studies conducted worldwide and in India have examined the effects of COVID-19 on these services, a significant gap in robust evidence remains.

Methods: Forty-two districts were selected randomly from seven regional states of India.

All-fiber E + S band continuously tunable bismuth-doped germanosilicate fiber laser.

In this Letter, we present an all-fiber bismuth (Bi)-doped germanosilicate fiber laser that is continuously tunable within the range of 1425-1475 nm, enabled by a tunable optical filter. A maximum output power of 86.4 mW was achieved at 1450 nm with a slope efficiency of 13.

Fluorescent zinc(II) thione and selone complexes for light-emitting applications.

Three 1-(anthracene-9-ylmethyl)-3-isopropyl-imidazol-2-thione Zn(II) halide complexes (1-3) and one 1-(anthracene-9-ylmethyl)-3-isopropyl-imidazol-2-selone Zn(II) dichloride complex (4) were synthesized and characterized. Complexes 2, 3, and 4 exhibited distorted tetrahedral geometries, while complex 1 adopted a regular tetrahedral geometry. All these complexes displayed emission in the crystalline state, with complex 3 emitting in the yellow region and complex 1 and 4 in the blue region, while complex 2 gave a bluish-green emission.

Plasmonic colorimetric sensor based on alpha-cyclodextrin-functionalized silver nanoparticles for the selective detection of arsenic(iii) in aqueous media.

The optical detection of arsenic (As) in human biological fluids and environmental water samples is presented using alpha-cyclodextrin-modified silver nanoparticles (α/CyD-AgNPs) at the trace level. This method is based on the measurement of a red shift of the LSPR band of α/CyD-AgNPs in the region of 200-800 nm. The color of α/CyD-AgNPs was changed from yellow to colorless by the addition of As(iii).

Anticancer Effects of Arsenic Compounds in Non-Small Cell Lung Cancer.

Non-small cell lung cancer (NSCLC) is the most common and prevalent subtype of lung cancer and continues to be one of the leading causes of cancer-related deaths worldwide. Despite various treatment options, a majority of NSCLC patients continue to experience disease progression and associated side effects, which are largely attributed to drug resistance, indicating the need for alternative strategies to combat this deadly disease. Among various applicable alternative approaches, repurposed drugs such as arsenic compounds have been shown to exert anticarcinogenic properties against NSCLC and possess the ability to overcome drug resistance mechanisms.

Significance of the Sparing Pronator Quadratus for Volar Plating of Distal Radius Fractures: A Prospective Study.

Background Pronator quadratus (PQ) acts as the pronator of the wrist and stabiliser of the distal radioulnar joint; it also provides a protective cover over the edge of the plate, preventing friction and subsequent rupture of flexor tendons. The repair of PQ is often difficult, and its durability is questionable; hence, preserving the PQ while volar plating distal radius fractures is advocated. Methods In this prospective randomised trial, 60 patients with a fracture of the distal end of the radius of AO-type (Arbeitsgemeinschaft für Osteosynthesefragen) 23 A2, A3, B1, B3, C1, and C2 were treated with volar plate fixation using either the PQ-releasing and repair approach (Group A, n = 30) or the PQ-sparing approach (Group B, n = 30), allowed by simple randomisation.

Recent trends in the treatment of vitiligo using novel drug delivery system.

Vitiligo is a complex dermatological disorder involving the loss of melanocytes, with resultant patches of depigmentation. It affects 1% of the world population, affecting patients' mental health and quality of life. With all the improvement seen, conventional treatment methods-steroids, phototherapy, and immunomodulators-come with the limitations of being less effective, having more side effects, and low compliance.

Recyclable copper catalyst supported over ceria for acceptorless dehydrogenative synthesis of quinolines.

This study presents a highly efficient and cost-effective Cu/CeO2 catalyst for the acceptorless dehydrogenative coupling (ADC) of o-aminobenzyl alcohols and secondary alcohols to synthesize quinolines. The catalyst demonstrated over 90% yield in quinoline production under mild conditions, exhibiting excellent tolerance to various functional groups. The Cu/CeO2 catalyst, synthesized via a co-precipitation method, was thoroughly characterized through various techniques like PXRD, XPS, and AC-STEM.

Risk Factors Associated With Gangrenous Cholecystitis: A Cohort Study From Eastern India.

Background: Treating gangrenous cholecystitis (GC) can be a challenge. It necessitates urgent intervention due to its elevated mortality risk. Prompt identification of risk factors and intervention are essential for halting inflammatory cascade and preventing further complications.

Correction to: Sustained attention detection in humans using a prefrontal theta-EEG rhythm.

[This corrects the article DOI: 10.1007/s11571-024-10113-0.].

Blocking feedback immunosuppression of antigen presentation in brain tumor during oncolytic virotherapy with oHSV-mshPKR.

Glioblastoma (GBM) is the most frequent malignant brain tumor. We recently discovered that oncolytic herpes simplex virus engineered to disable tumor-intrinsic protein kinase R (PKR) signaling (oHSV-shPKR) could increase oHSV oncolysis and anti-tumor immune response. However, here we show that disabling tumor-intrinsic PKR signaling can also induce the activation of the indoleamine 2,3-dioxygenase (IDO) signaling pathway.

GC-MS and HPTLC Fingerprinting Analysis and Evaluation of Antimicrobial Activity of Naga Chilli: An In Vitro and In Silico Approach.

Naga chilli (Capsicum chinense Jacq.) have garnered significant attention due to the plant's possible health benefits and variety of phytochemical components. Utilizing cutting-edge analytical techniques such as gas chromatography-mass spectrometry (GC-MS) and high-performance thin layer chromatography (HPTLC) in conjunction with bioautography, this study conducts a thorough phytochemical profiling and biological activity assessment of the Naga chilli plant.

Exploring the role of pomalidomide in androgen-dependent prostate cancer: a computational analysis.

Prostate cancer (PC) is among the most prevalent cancers in males. It is the leading cause of death in men, in around 48 out of 185 countries. Increased androgen receptor (AR) activity is the key factor contributing to the development or progression of newly diagnosed cases of prostate cancer.

Relevance of the Platelet-activating factor system in chemical warfare agents-induced effects.

The threats to chemical warfare-associated agents (CWA), including nitrogen mustard, are increasing, and no direct antidote is currently available to mitigate the deleterious cutaneous and systemic responses to prevent mortality. Though most of these agents act as alkylating agents, a significant knowledge gap exists in the molecular mechanisms of how these vesicants cause toxic effects. Studies, including ours, have shown that exposure to reactive oxygen species (ROS)-generating stimuli, including alkylating chemotherapeutic agents, and thermal burn injuries with ethanol produce the potent family of lipid mediators, Platelet-activating factor (PAF) agonists that induce local inflammation, and multi-system organ dysfunction (MOD).

Smoking carcinogen induced inflammation promotes lung carcinogenesis via IRAK4 activation.

Purpose: Even though smoking is associated with lung cancer, the exact molecular pathways that link carcinogens with inflammation and oncogenic transformation are not well elucidated. Two major carcinogens in cigarette smoke, Nicotine-derived nitrosamine ketone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo(α)pyrene (BaP) have not been tested in models that mimic inhaled exposure for prolonged periods of time.

Experimental Design: ICR mice were treated with intratracheal delivery of NNK and BaP (NB) for 18 months.

Histopathological changes in various organs in electrocution deaths.

Death due to electrical injuries are a major health concern and has a high rate of morbidity and mortality. Electrocution death is defined as that occurring due to passage of electric current inside the body and is obviously a form of unnatural death. The cause includes ventricular fibrillation, paralysis of respiratory muscles and the central respiratory centre.