Evaluation of A. DC. Leaves and Its Isolated Secondary Metabolites as Natural Anti-Toxoplasma and Anti-Cancer Agents Using In Vitro and In Silico Studies.

Toxoplasmosis and cancer are life-threatening diseases with worldwide distribution. However, currently used chemosynthetic treatments are not devoid of their own intrinsic problems. Natural metabolites are gaining attention due to their lower side effects.

Toxoplasmocidal and Cytotoxic Activities Guided Isolation and Characterization of an Undescribed Bioflavonoid-di--glucoside from Miq. Cultivated in Egypt.

Toxoplasmosis and cancer are serious worldwide diseases, and the available drugs cause serious side effects. Investigation for new alternative therapies from natural sources is now an increasing concern. Herein, we carried out, for the first time, an in vitro screening of Miq.

In Vitro Characterization of Inhibitors for Lung A549 and Leukemia K562 Cell Lines from Fungal Transformation of Arecoline Supported by In Silico Docking to M3-mAChR and ADME Prediction.

The search for anticancer drugs is of continuous interest. Arecoline is an alkaloid with anticancer activity. Herein, the metabolism of arecoline through fungal transformation was investigated for the discovery of potential anticancer drugs with higher activity and selectivity.

Triterpenoids from the aerial parts of (Forssk) Moq: gastroprotective effect in vivo with in silico studies, cytotoxic and antimicrobial activities.

A new triterpenoid named 3,20-dihydroxy-30-nor-olean-12-ene-23,28 dioic acid ( along with 3-hydroxy-23-aldehyde-lup-20(29)-ene-28-oic acid (, 3-hydroxy-23-aldehyde-30-nor-olean-12,20(29)-diene-28-oic acid (, 3-hydroxy-lup-20(29)-ene-23,28 dioic acid ( 3-hydroxy-lup-20(29)-ene-23,28 dioic acid-23---D-glucopyranosyl ester (, 3---D-glucuronopyranosyl-lup-20(29)-ene-23,28 dioic acid-28---D-glucopyranosyl ester (, 3---D-glucuronopyranosyl-lup-20(29)-ene-23-aldehyde-28-oic acid-28---D glucopyranosyl ester ( were isolated for the first time from the aerial parts of (Forssk) Moq. Isolated pure compounds were structurally elucidated using spectral analysis. Cytotoxic, antimicrobial, antiulcer activities and antioxidant parameters were evaluated using the total methanol extract and its successive fractions.

Hepatoprotective, cytotoxic, antimicrobial and antioxidant activities of leaves Dyer Ex Eichler and its isolated secondary metabolites.

Given the lack of adequate research on () Dyer Ex Eichler, this study was conducted focusing on different biological activities and phytochemical investigation of for the first time. showed strong protective activity against DNA damage and potent activity against VERO cell line. It also presented antimicrobial and hepatoprotective activity.