Chromatin modifiers - Coordinators of estrogen action.

A group of hormones, called estrogens, are pivotal drivers of various physiological processes. Expectedly, estrogen-driven actions are also relevant modulators of pathophysiological changes, including cancer. Different transcriptional and tissue-specific responses are elicited mainly by two estrogen receptor (ER) isoforms, ERα and ERβ.

The mA RNA Modification Quantity and mRNA Expression Level of RNA Methylation-Related Genes in Head and Neck Squamous Cell Carcinoma Cell Lines and Patients.

RNA methylation at the nitrogen sixth of adenosine (mA, -methyladenosine) is the most abundant RNA modification which plays a crucial role in all RNA metabolic aspects. Recently, mA modification has been assigned to mediate the biological processes of cancer cells, but their significance in HNSCC development is still poorly described. Thus, the main aim of this study was to globally quantify mA modification by the mass spectrometry approach and determine the mRNA expression level of selected mA RNA methyltransferase (METTL3), demethylase (FTO), and mA readers (YTHDF2, YTHDC2) in 45 HNSCC patients and 4 cell lines (FaDu, Detroit 562, A-253 and SCC-15) using qPCR.

Head and Neck Squamous Cell Carcinoma: Epigenetic Landscape.

Head and neck squamous carcinoma (HNSCC) constitutes the sixth most prevalent cancer worldwide. The molecular pathogenesis of HNSCC includes disorders in cell cycle, intercellular signaling, proliferation, squamous cell differentiation and apoptosis. In addition to the genetic mutations, changes in HNSCC are also characterized by the accumulation of epigenetic alterations such as DNA methylation, histone modifications, non-coding RNA activity and RNA methylation.

A new quill mite Torotrogla emberizae sp. nov. (Acariformes: Syringophilidae) from the Chestnut-eared Bunting (Passeriformes: Emberizidae) in Japan (morphology and DNA barcode data).

A new quill mite Torotrogla emberizae sp. nov. (Acariformes: Syringophilidae) parasitizing the Chestnut-eared Bunting Emberiza fucata Pallas, 1776 (Passeriformes: Emberizidae) in Japan is described based on the external morphology and DNA barcode data (mitochondrial cytochrome c oxidase subunit I sequences, COI).

Combined description (morphology with DNA barcode data) of a new quill mite Torotrogla paenae n. sp. (Acariformes: Syringophilidae) parasitising the Kalahari scrub-robin Cercotrichas paena (Smith) (Passeriformes: Muscicapidae) in Namibia.

A new quill mite species Torotrogla paenae n. sp. (Acariformes: Syringophilidae) parasitising the Kalahari scrub-robin Cercotrichas paena (Smith) (Passeriformes: Muscicapidae) in Namibia is described based on the external morphology and DNA barcode data (the mitochondrial cytochrome c oxidase subunit 1 sequences, cox1).