Publications by authors named "Kamil OEnder"
Article Synopsis
- HER2 expression is crucial in breast cancer for determining metastatic potential, recurrence rates, and response to targeted therapies, but current testing methods such as FISH and IHC suffer from standardization and technical issues.* -
- The study evaluated the use of RT-qPCR for HER2 testing in breast cancer, finding that using laser-captured microdissection significantly improved accuracy compared to standard tumor tissue analysis.* -
- Results indicated that RT-qPCR, when combined with microdissection, is a reliable and cost-effective method for HER2 testing, with potential for better classification of ductal carcinomas based on HER3 and HER4 expression.*
Article Synopsis
- The study explores the impact of cytoskeletal proteins on intrinsic skin aging, focusing on keratins and other cytoskeletal components in young versus aged human foreskin samples.
- It found that several keratins (K1, K3, K4, K9, K13, K15, K18, K19, K20) are downregulated in older skin, while others (K2, K16, K17) are upregulated, indicating a complex response in aging.
- In contrast, key cytoskeletal proteins like junction-plakoglobin, alpha-tubulin, and beta-actin are all decreased in aged skin, emphasizing the need for balanced evaluation of RNA and protein expressions in aging research
Article Synopsis
- - The yeast ribosome consists of two subunits (60S and 40S) and contains 78 ribosomal proteins, with many encoded by duplicate genes.
- - Deleting specific ribosomal protein genes (like RPL31A, RPL6B, and RPS6B) significantly increased yeast replicative life span, with some deletions extending lifespan by up to 45%.
- - Manipulating the gene dosage of ribosomal proteins impacted ribosome levels and growth rate, suggesting that these changes in translation regulation may play a role in the aging process of yeast.
Article Synopsis
- The study investigates the role of a mutation in the 3'UTR of the C1 inhibitor gene in relation to hereditary angioedema (HAE).
- Researchers found a 155 bp deletion in affected family members that reduced both mRNA and C1-INH protein levels.
- The conclusion suggests that this mutation disrupts gene expression pathways, causing a deficiency that leads to HAE symptoms in the family.
Functional ribosomes synthesize proteins in all living cells and are composed of two labile associated subunits, which are made of rRNA and ribosomal proteins. The rRNA of the small 40S subunit (SSU) of the functional eukaryotic 80S ribosome decodes the mRNA molecule and the large 60S subunit (LSU) rRNA catalyzes protein synthesis. Recent fine structure determinations of the ribosome renewed interest in the role of ribosomal proteins in modulation of the core ribosomal functions.
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- The biogenesis of ribosomes and cell surface components are crucial for yeast cell growth, with specific proteins like RpL10p/Grc5p playing key roles in ribosome assembly and maturation.* ! -
- A study found that the yeast genes SED1, ACS2, and PLB3 interact with RpL10p/Grc5p and its human counterpart, indicating a connection between ribosome function and cellular metabolism.* ! -
- The protein Sed1p is suggested to have a significant role in translating ribosomes and is involved in cell wall formation, while ACS2 and PLB3 are linked to lipid synthesis and membrane maintenance, respectively.* !