Publications by authors named "Kamil Lisiecki"
Article Synopsis
- OATD-02 is a newly developed oral drug that inhibits arginases 1 and 2 (ARG1 and ARG2), which are enzymes linked to immune regulation in cancer.
- The drug shows strong potential to combat tumor-related immune suppression and improve the effectiveness of other cancer treatments.
- Nonclinical studies suggest that OATD-02 has favorable pharmacologic properties, making it a promising candidate for clinical trials in cancer patients.
Podophyllotoxin (PPT) is an antimitotic drug used topically in the treatment of anogenital warts. Due to its toxicity it cannot be administered systemically as an anticancer agent. However, modified PPT derivatives such as etoposide and teniposide are used clinically as systemic agents.
View Article and Find Full Text PDFAnti-prion drug screening system in Saccharomyces cerevisiae based on an artificial [LEU2] prion.
Fungal Genet Biol
January 2020
Article Synopsis
- Researchers are studying prions, which are infectious proteins linked to serious brain diseases in mammals, using a yeast-based screening system for potential anti-prion drugs.
- The existing screening method, the white/red colony assay, has limitations in quantifying drug effectiveness and can be affected by other cellular factors.
- The article introduces a new yeast-based system using an artificial prion, [LEU2], which confirmed the activity of some anti-prion drugs and showed improved sensitivity compared to the previous white/red system.
Article Synopsis
- The first total synthesis of (+)-epigalcatin was achieved using piperonal, 3,4-dimethylbenzaldehyde, and diethyl succinate as starting materials.
- A chiral auxiliary, l-Prolinol, was utilized to ensure stereoselectivity during the process.
- A key step in the synthesis was the continuous-flow photocyclization that constructed the cyclolignan framework from a specific chiral compound.
Article Synopsis
- Researchers have developed a stereoselective synthesis strategy for cyclolignans related to podophyllotoxin and its derivatives.
- The key step involves photocyclization of a specific chiral compound, which is made from aromatic aldehydes and diethyl succinate.
- Using a continuous flow photochemical reactor increases efficiency and scalability, leading to the production of cytotoxic compounds that can be further reduced to synthesize (-)-podophyllotoxin.