Cingulum bundle white matter lesions influence antidepressant response in late-life depression: a pilot study.

Background: Late-life depression is associated with white matter hyperintense lesions (WMLs) occurring in specific fiber tracts. In this study, we sought to determine if greater WML severity in the cingulum bundle or uncinate fasciculus was associated with poor short-term antidepressant response.

Methods: Eleven depressed elders completed a baseline cranial 3T MRI and received antidepressant treatment following a medication algorithm.