Publications by authors named "Kamil Adamiak"
Article Synopsis
- Abnormal protein deposition and spread are key factors in neurodegenerative disorders, leading to significant cellular damage.
- Diseases like Parkinson's and Alzheimer's involve the aggregation of proteins such as α-synuclein and Tau, resulting in neuronal loss and associated symptoms.
- Current research is focused on developing therapies to inhibit these harmful protein misfolding and aggregation processes, offering hope for better treatment options.
The extensive production and use of plastics in recent decades has led to environmental pollution. It has been discovered that plastic microparticles (MPs) and nanoparticles (NPs), formed under the influence of physical forces, can pose a significant health risk. Increasing evidence indicates that NPs can have various toxic effects, including oxidative stress and cell death.
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- Astroglia are the largest type of glial cells and play vital roles in supporting neurons, including maintaining the blood-brain barrier and forming synapses.
- Neurodegenerative diseases, like tauopathies, significantly impact astroglial functions, often before symptoms appear.
- This review examines the glutamate-glutamine cycle (GGC) and how its disruption contributes to tau-dependent neurodegeneration, highlighting the importance of understanding these processes for developing new treatments.