Gene Mutation Prevalence in Triazole-Resistant Clinical Isolates.

Recently, mutations in the -encoding gene (), a gene involved in ergosterol production, were associated with triazole-resistance in . In this study, we determined the prevalence and characteristics of mutations in a collection of clinical triazole-resistant isolates collected during 2001-2019 from two international mycology reference centers: the Belgian National Reference Center for Mycosis and the Center of Expertise in Mycology Radboudumc/CWZ. Clinical isolates with and without gene mutations and randomly selected wild-type (WT) controls were included.