Analgesic activity of certain flavone derivatives: a structure-activity study.

1. Flavone, its methoxy derivatives and flavanone were synthesized by standard methods and were tested for analgesic activity in mice by employing acetic acid writhing and tail flick methods. 2.

Analgesic activity of certain flavone derivatives: a structure-activity study.

Flavone and 10 hydroxy and glucoside flavone derivatives were synthesised. They were tested for their analgesic effect in mice employing acetic acid-induced writhing and tail immersion methods. Subcutaneously all the tested compounds exhibited significant analgesic activity with varying potencies in both assay models.

Effect of leucas aspera on experimental inflammation and mast cell degranulation.

The aqueous and alcoholic extracts of Leucas aspera were investigated for their action on experimental inflammation and on mast cell degranuatlion. Both the extracts exhibited significant antiinflammatory action of acute and chronic inflammation. The mast cell drgranulation induced by proprancolol and Carbachol was effectively prevented by pretreatment with Leucas aspera extracts.

Serum uric acid concentrations in offspring of conjugal diabetic parents.

Serum uric acid concentrations were measured in offspring of conjugal diabetic parents, in diabetic patients, and in matched nondiabetic controls. The mean uric acid level in offspring of conjugal diabetic parents was significantly higher than in the controls and diabetic patients (P less than 0.001 in the nonobese and P less than 0.

Flavonoid-induced delay in the small intestinal transit: possible mechanism of action.

Three flavonoids viz: gossypin, epicatechin and hydroxyethyl rutosides were evaluated for their effect on small intestinal transit in mice. All the three flavonoids delayed the small intestinal transit in a dose-dependent manner. Naloxone, yohimbine and phentolamine antagonized the inhibitory effect of flavonoids, while it was not altered by prazosin, propranolol, atropine, physostigmine, hexamethonium, pheniramine or metiamide.

Gossypin-induced analgesia in mice.

A flavonoid, gossypin, was evaluated for its analgesic action by using acetic acid-induced writhing in mice and was compared with morphine. Gossypin inhibited writhing in a dose-dependent manner. This action was antagonised by naloxone.

Therapeutic compliance of patients on phenothiazines.

The present study was designed to assess the therapeutic compliance of psychiatric patients who reported to be on regular medication particularly phenothiazines. Of the all cases subjected to the F.P.

Pharmacological profile of mangostin and its derivatives.

Mangostin (M), a naturally occurring xanthone in the rinds of the fruits of Garcinia mangostana Linn. (Guttiferae) and its derivatives such as 3-0-methyl mangostin (MM), 3,6-di-O-methyl mangostin (DM), 1-isomangostin (IM), mangostin triacetate (MT), mangostin 3,6-di-O-(tetra acetyl) glucoside (MTG) and mangostin-6,6-di-O-glucoside (MOG) were screened for various pharmacological effects in experimental animals. With the exception of DM all the test compounds produced CNS depression characterised by ptosis, sedation, decreased motor activity, potentiation of pentobarbital sleeping time and ether anaesthesia in mice and rats.

Effect of naloxone on the sensitivity of the vas deferens to various agonists.

The effect of naloxone in vitro, on noradrenaline (NA)-induced responses in guinea-pig isolated vas deferens was studied. The responses of NA were potentiated by naloxone (3 microM). It potentiated the responses to methoxamine which has least affinity for uptake sites.

Carbachol-induced sensitivity changes in skeletal muscle and their mechanism of action.

Pretreatment of carbachol (in vitro), in various doses (5.5 pM to 550 nM), produced a significant decrease in the sensitivity of the frog rectus abdominis muscle to acetylcholine (ACh), in a dose-dependent manner. This action was observed with a 60 min incubation period.

Studies on the pharmacological actions of Cardiospermum helicacabum.

The leaves of the plant "Cardospermum helicacabum" were extracted with different solvents and found to contain largely tannins, saponins and traces of alkaloids. The alcoholic extract was tested for its pharmacological effects on various intact and isolated biological preparations. On the CNS the extract produced depression in near lethal doses.