Publications by authors named "Kamesh R Babu"
Article Synopsis
- Quantum dots (QDs) are tiny semiconducting nanoparticles that have unique optical and electrical properties, such as glowing under UV light due to electron transitions.
- Their characteristics, like high brightness, photostability, and low toxicity, make them ideal for various biomedical applications including bioimaging, diagnostics, and drug delivery.
- The study also highlights the benefits and limitations of using QDs compared to conventional biomedical tools.
The Yin-Yang Regulation of Reactive Oxygen Species and MicroRNAs in Cancer.
Int J Mol Sci
October 2019
Article Synopsis
- Reactive oxygen species (ROS) are reactive chemicals produced during normal cell respiration and other enzymatic processes, acting as important messengers in cell signaling related to growth, survival, and immune responses.
- While ROS play vital roles in cell signaling, excessive levels can lead to DNA damage and promote cancer by activating harmful pathways.
- Recent research highlights the complex relationship between ROS and microRNAs (miRNAs), as ROS influence miRNA expression and function, while miRNAs help maintain balance in ROS levels, impacting cancer development and progression.
Article Synopsis
- RNA-binding proteins (RBPs) play a crucial role in regulating RNA-related processes and are often dysregulated in cancers.
- A study analyzed RBP expression across 16 human cancer types, finding that many RBPs are upregulated and influenced by tumor immune subtypes and the microenvironment.
- The research identified specific RBPs with consistent dysregulation across cancers, including PABPC1L, which may contribute to colon cancer progression, highlighting their potential as targets for new cancer treatments.
Transferrin receptor 1 (TFR1) is a transmembrane glycoprotein that allows for transferrin-bound iron uptake in mammalian cells. It is overexpressed in various cancers to satisfy the high iron demand of fast proliferating cells. Here we show that in hepatocellular carcinoma (HCC) TFR1 expression is regulated by miR-148a.
View Article and Find Full Text PDFmiR-20a regulates expression of the iron exporter ferroportin in lung cancer.
J Mol Med (Berl)
March 2016
Unlabelled: Ferroportin (FPN) exports iron from duodenal enterocytes, macrophages, and hepatocytes to maintain systemic iron homeostasis. In addition, FPN is expressed in various cancer cells. Here, we show that in lung cancer, FPN expression is regulated by miR-20a.
View Article and Find Full Text PDFPancreatic ductal adenocarcinoma (PDA) has the worst prognosis of all malignancies, and current therapeutic options do not target cancer stem cells (CSCs), which may be the reason for the extreme aggressiveness. The dietary agents sulforaphane and quercetin enriched e.g.
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