Publications by authors named "Kamelya Aliakbari"
Trinucleotide repeat disorders comprise ~20 severe, inherited, human neuromuscular and neurodegenerative disorders, which result from an abnormal expansion of repetitive sequences in the DNA. The most common of these, Huntington's disease (HD), results from expansion of the CAG repeat region in exon 1 of the gene via an unknown mechanism. Since non-coding RNAs have been implicated in the initiation and progression of many diseases, herein we focused on a circular RNA (circRNA) molecule arising from non-canonical splicing (backsplicing) of pre-mRNA.
View Article and Find Full Text PDFBackground: Previous research has shown diminished nasal immune function following nasal saline irrigation (NSI), returning to baseline at 6 hours. The aim of this study was to examine the immune nasal proteome before and after 14 days of nasal irrigation.
Methods: Seventeen healthy volunteers received either isotonic (IsoSal) or low salt (LowNa) NSI.
Article Synopsis
- Peanut allergies affect 1%-3% of children in Western countries, and the study aimed to test oral immunotherapy (OIT) using boiled peanuts to help desensitize these allergic children.* -
- The clinical trial involved 70 participants aged 6-18 and included a gradual increase in boiled peanuts followed by roasted peanuts over several weeks, aiming for a daily maintenance dose.* -
- Results showed 80% of participants successfully desensitized, with few treatment-related adverse events, indicating that this method may be a safe and effective way to manage peanut allergies in children.*
Alpha-1antitrypsin (A1AT) deficiency, an inherited disorder, has been shown to be the cause of lung diseases such as emphysema and chronic obstructive pulmonary disease. One of the treatment strategies to provide appropriate and adequate concentrations of A1AT in the lungsis the application of nanoparticles (NPs) in pulmonary drug delivery. In the current study, biocompatible nanohydrogels were prepared using chemically cross-linked chitosan with ginepin, a natural cross linker reagent, and used as a carrier to deposit A1AT into the lung tissue.
View Article and Find Full Text PDFVascular dysfunction is an early feature of diabetic vascular disease, due to increased oxidative stress and reduced nitric oxide (NO) bioavailability. This can lead to endothelial cell senescence and clinical complications such as stroke. Cells can become senescent by shortened telomeres and oxidative stress is known to accelerate telomere attrition.
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