Impact of solid waste dumping on soil quality and its potential risk on human health and environment.

The soil, comprising minerals, organic matter, and living organisms, serves as a critical component of our environment. However, anthropogenic activities, such as uncontrolled sewage disposal and industrial waste, have led to pervasive soil pollution, impacting ecosystems and human health. This comprehensive study scrutinizes the intricate dynamics of soil pollution resulting from open waste dumping, specifically examining its impact on the health of local communities and the environment in Haridwar municipality.

Solitary Bone Plasmacytoma Mimicking Oral Cavity Neoplasm - A Rare Case.

Plasmacytomas are localized monoclonal plasma cell lesions with no evidence of systemic involvement which are divided into solitary bone plasmacytoma (SBP) and extra-medullary plasmacytoma (EMP). The diagnosis of plasmacytomas (PCM) in the oral regions is challenging given the atypical clinical manifestations and low frequency. Here, we report an extremely rare case of plasmacytoma in an elderly male which initially appeared to be arising from the left buccal mucosa on clinical examination but after radiological imaging and intra-operative findings, the epicentre was found to be in the left infratemporal fossa (ITF).

Effect of formalin fixation on tumour size and margins in head and neck cancer specimens.

Objectives: To quantify tumour size and margin shrinkage due to formalin fixation in head and neck cancer specimens and determine its effect on tumour staging and margin clearance.

Methods: Tumour specimens were measured immediate post-resection and at 24 hours after fixation. Tumour was measured in 2 dimensions and one margin was measured.

An observational multi-centric COVID-19 sequelae study among health care workers.

Background: India has seen more than 43 million confirmed cases of COVID-19 as of April 2022, with a recovery rate of 98.8%, resulting in a large section of the population including the healthcare workers (HCWs), susceptible to develop post COVID sequelae. This study was carried out to assess the nature and prevalence of medical sequelae following COVID-19 infection, and risk factors, if any.

Hybridizing slime mould algorithm with simulated annealing algorithm: a hybridized statistical approach for numerical and engineering design problems.

The existing slime mould algorithm clones the uniqueness of the phase of oscillation of slime mould conduct and exhibits slow convergence in local search space due to poor exploitation phase. This research work exhibits to discover the best solution for objective function by commingling slime mould algorithm and simulated annealing algorithm for better variation of parameters and named as hybridized slime mould algorithm-simulated annealing algorithm. The simulated annealing algorithm improves and accelerates the effectiveness of slime mould technique as well as assists to take off from the local optimum.

A boosted chimp optimizer for numerical and engineering design optimization challenges.

Chimp optimization algorithm (ChoA) has a wholesome attitude roused by chimp's amazing thinking and hunting ability with a sensual movement for finding the optimal solution in the global search space. Classical Chimps optimizer algorithm has poor convergence and has problem to stuck into local minima for high-dimensional problems. This research focuses on the improved variants of the chimp optimizer algorithm and named as Boosted chimp optimizer algorithms.

COVID-19 Vaccines: Speedy Development and their Use to be Saviour of Humanity.

COVID-19 disease is caused by a novel coronavirus (SARS-CoV-2), and it was declared as a pandemic by WHO within two and half months of detection of first case. The pandemic situation induced unprecedented cooperation amongst countries, academia, public sector institutions and industry in sharing knowledge, resources and strategies. In this article, development of vaccines and their delivery system is discussed.

An effective solution to numerical and multi-disciplinary design optimization problems using chaotic slime mold algorithm.

Slime mold algorithm (SMA) is a recently developed meta-heuristic algorithm that mimics the ability of a single-cell organism (slime mold) for finding the shortest paths between food centers to search or explore a better solution. It is noticed that entrapment in local minima is the most common problem of these meta-heuristic algorithms. Thus, to further enhance the exploitation phase of SMA, this paper introduces a novel chaotic algorithm in which sinusoidal chaotic function has been combined with the basic SMA.

Early Detection of Covid-19 in Canadian Provinces and its Anticipatory Measures for a Medical Emergency.

The spread of COVID-19 is incearsing day by day and it has put the entire world and the whole humankind at the stack. The assets of probably the biggest economies are worried because of the enormous infectivity, and transmissibility of this ailment. Because of the developing extent of the number of cases and its ensuing weight on the organization and wellbeing experts, some expectation strategies would be required to anticipate the quantity of evidence in the future.

Palmitic Acid-Pluronic F127-Palmitic Acid Pentablock Copolymer as a Novel Nanocarrier for Oral Delivery of Glipizide.

Objectives: The aim of the present study was to develop nanotechnology-based oral formulations of glipizide to enhance the bioavailability and eliminate the frequent oral administration of the conventional dosage form. Glipizide is an antidiabetic drug with a short biological half-life and limited oral bioavailability. Novel palmitic acid-pluronic F127-palmitic acid (PA-F127) pentablock copolymer-based prolonged release glipizide nanoparticles (GNs) were prepared and screened for and studies.

Spatial and temporal variation of zooplankton assemblage in the mining-impacted stretch of Ganga River, Uttarakhand, India.

The spatial and temporal variation in the distribution, abundance and assemblage structure of zooplankton were examined in a mining-impacted stretch of river Ganga. The collection of samples has been done from three different sampling zones such as Z1 (Chandi Bridge Ghat) as reference zone, Z2 (Shyampur), and Z3 (Bisanpur) as mining-intruded area from May 2017 to April 2018. During the analysis, twenty-eight species of zooplankton kindred to four groups mainly Rotifera (ten species), Protozoa (five species), Cladocera (eight species), and Copepoda (five species) were identified.

A general approach for hysteresis-free, operationally stable metal halide perovskite field-effect transistors.

Despite sustained research, application of lead halide perovskites in field-effect transistors (FETs) has substantial concerns in terms of operational instabilities and hysteresis effects which are linked to its ionic nature. Here, we investigate the mechanism behind these instabilities and demonstrate an effective route to suppress them to realize high-performance perovskite FETs with low hysteresis, high threshold voltage stability (ΔV < 2 V over 10 hours of continuous operation), and high mobility values >1 cm/V·s at room temperature. We show that multiple cation incorporation using strain-relieving cations like Cs and cations such as Rb, which act as passivation/crystallization modifying agents, is an effective strategy for reducing vacancy concentration and ion migration in perovskite FETs.

Systematic Study of Ferromagnetism in CrSbTe Topological Insulator Thin Films using Electrical and Optical Techniques.

Ferromagnetic ordering in a topological insulator can break time-reversal symmetry, realizing dissipationless electronic states in the absence of a magnetic field. The control of the magnetic state is of great importance for future device applications. We provide a detailed systematic study of the magnetic state in highly doped CrSbTe thin films using electrical transport, magneto-optic Kerr effect measurements and terahertz time domain spectroscopy, and also report an efficient electric gating of ferromagnetic order using the electrolyte ionic liquid [DEME][TFSI].

The Unprecedented Role of Gold Nanomaterial in Diabetes Management.

Gold nanoparticles possess unique mechanical, chemical, photo-optical and biological properties and have been an interesting field of research on life sciences. The research studies produced new nanodevices and nanotechnology-based biosensing, diagnostics therapeutics, and targeted drug delivery systems. In this review, the unique potential aspects of gold nanoparticles/ nanoformulations/ or devices related to diabetes management have been discussed together with the recent patent on the gold nanoparticles developed for diabetes management.

Audiological profiling in postmenopausal women with osteoporosis.

Objectives: To compare the audiological profiles in postmenopausal women with and without osteoporosis and to study the pattern of hearing loss in osteoporotic patients.

Materials And Methods: 80 postmenopausal women were evaluated at a tertiary referral center and were divided into normal, osteopenic and osteoporotic based on BMD results. The hearing evaluation was done using PTA, Impedance audiometry and DPOAE and the results were compared between the groups and analyzed.

Is Pterygopalatine Fossa Injection with Adrenaline an Effective Technique for Better Surgical Field in Fess?

Functional endoscopic sinus surgery (FESS) is one of most common surgeries in otorhinolaryngology practice. It is done in the narrow confines of the nasal cavity. Bleeding into the surgical field is a major problem faced by endoscopic surgeons.

Centchroman: A safe reversible postcoital contraceptive with curative and prophylactic activity in many disorders.

Centchroman (INN: Ormeloxifene), a reversible post-coital/weekly oral contraceptive (half-life of about 168 hours), designed and developed at CDRI, Lucknow is the only non-steroidal oral contraceptive in clinical use in the world today. Synthesized in 1967 and completing pre-clinical and clinical studies in 1989, this drug was approved for marketing in 1991, social marketing in 1995 and NFPW in April 2016. It acts by preventing implantation of blastocyst in endometrium.

Contactless graphene conductivity mapping on a wide range of substrates with terahertz time-domain reflection spectroscopy.

We demonstrate how terahertz time-domain spectroscopy (THz-TDS) operating in reflection geometry can be used for quantitative conductivity mapping of large area chemical vapour deposited graphene films on sapphire, silicon dioxide/silicon and germanium. We validate the technique against measurements performed with previously established conventional transmission based THz-TDS and are able to resolve conductivity changes in response to induced back-gate voltages. Compared to the transmission geometry, measurement in reflection mode requires careful alignment and complex analysis, but circumvents the need of a terahertz transparent substrate, potentially enabling fast, contactless, in-line characterisation of graphene films on non-insulating substrates such as germanium.

External amplitude and frequency modulation of a terahertz quantum cascade laser using metamaterial/graphene devices.

Active control of the amplitude and frequency of terahertz sources is an essential prerequisite for exploiting a myriad of terahertz applications in imaging, spectroscopy, and communications. Here we present a optoelectronic, external modulation technique applied to a terahertz quantum cascade laser which holds the promise of addressing a number of important challenges in this research area. A hybrid metamaterial/graphene device is implemented into an external cavity set-up allowing for optoelectronic tuning of feedback into a quantum cascade laser.

High Open-Circuit Voltages in Tin-Rich Low-Bandgap Perovskite-Based Planar Heterojunction Photovoltaics.

Low-bandgap CH NH (Pb Sn )I (0 ≤ x ≤ 1) hybrid perovskites (e.g., ≈1.

1,2,4-triazole derivatives as potential scaffold for anticonvulsant activity.

The search for new anticonvulsant agent with more selectivity and lower toxicity continues to be an area of rigorous investigation in medicinal chemistry. Epilepsy is a chronic disorder of brain whose treatment consists of controlling seizures with antiepileptic drugs that very often related with side-effects which in rare circumstances can be potentially life-threatening. Triazolam and Alprazolam are established drugs used in epilepsy which have triazole moiety.

HPTLC method for estimation of olmesartan medoxomil in tablet formulation with stability studies.

A rapid resolution high performance thin layer chromatography (HPTLC) method has been developed and validated for estimation of olmesartan medoxomil in tablet formulations. This paper describes accurate, precise, specific and reproducible method and its degradation products, related impurities for assessment of purity of bulk drug and stability of its tablet formulations. The method involve silica gel 60 F254 high performance thin layer chromatography and densitometric detection at 264 nm using toluene - acetonitrile- methanol - ethyl acetate - acetic acid (5:3.