Rhodium(III)-Catalyzed Regioselective C-H Alkenylation and Alkylation of Menadione Analogues with β-Trifluoromethyl Enones.

Menadione and its structural analogues are important motifs present in various bioactive natural products and drugs with a wide range of biological activities. In addition, β-trifluoromethyl enone has been employed as an efficient fluorinated building block for the synthesis of CF-containing organic scaffolds. Herein, we report both C-H alkenylation and C-H alkylation reactions using β-CF enones as coupling partners with amino-substituted menadiones under Rh(III) catalysis.

A novel SERPINC1 c.119G>A (p.Cys40Tyr) mutation with variable clinical expression in an Indian family.

Hereditary antithrombin (AT) deficiency due to mutations in SERPINC1 is known to be the most severe form of thrombophilia. We report three members in a family with hereditary AT deficiency with a novel mutation in exon 2 of SERPINC1, that is c.119 G>A (p.

Electron-Deficient Indenofluorene-Based Systems: Multicolor and Visible-To-Near-Infrared (NIR) Electrochromism and OFF-OFF-ON Electrofluorochromism.

Multifunctional electrochromic systems with divergent functions are highly sought after but rare and challenging to develop. Here, we report the synthesis and multi-functional electrochromic behaviour (multi-colour modulation, visible-to-near IR absorption switching, and electrofluorochromism) of electron-deficient indenofluorene-based systems. The compounds (IF-IF) have been obtained via Knoevenagel condensation of indenofluorenone (IF) with various nucleophiles (malononitrile, benzylcyanide, dimethyl malonate, methyl cyanoacetate, benzothiazole-2-acetonitrile).

Comparative Evaluation of Antimicrobial Efficacy of Triple Antibiotic Paste Herbal Combination and Camphorated Monochlorophenol as Intracanal Medicaments against in Deciduous Molars: An Study.

Aim: Compare the efficacy of triple antibiotic paste (TAP), herbal extracts, and camphorated monochlorophenol (CMCP) as intracanal medicaments against () in deciduous molars.

Materials And Methods: A total of 60 samples were collected from canals of first and second molars of 4-10-year-old children, with more than two-thirds root length, and fitting the inclusion criteria. Samples were collected at three intervals-S1 was collected just after access opening, S2 was collected after biomechanical preparation (BMP) and irrigation, and just before placement of medicament.

Molecular Dialogue During Host Manipulation by the Vascular Wilt Fungus .

Vascular wilt fungi are a group of hemibiotrophic phytopathogens that infect diverse crop plants. These pathogens have adapted to thrive in the nutrient-deprived niche of the plant xylem. Identification and functional characterization of effectors and their role in the establishment of compatibility across multiple hosts, suppression of plant defense, host reprogramming, and interaction with surrounding microbes have been studied mainly in model vascular wilt pathogens and .

A Case Report on Internal Hernia as an Unusual Cause of Small Bowel Obstruction: A Diagnostic Triumph Unveiled by Computed Tomography Scan.

Paraduodenal hernia is a type of internal hernia caused by defects in the peritoneum during fetal development. It is one of the uncommon causes of intestinal obstruction; diagnosing it and intervening promptly are required. In this case report, we describe our experience treating an adult male patient who presented with symptoms of acute small bowel obstruction and was later diagnosed with internal hernia on further evaluation.

Exploring the diversity of vaginal microbiota between healthy women and cervical cancer patients in India.

Cervicovaginal diversity has been reported as a predictive biomarker for cervical cancer risk. We recently reported the bio-therapeutic potential of vaginal probiotics from healthy Indian women against vaginal pathogens, isolated from the invasive cervical cancer (ICC) patients. The cervicovaginal microflora from cervical cancer patients has not yet been reported from Indian population.

Structural and Functional Characterization of Obesumbacterium proteus Phytase: A Comprehensive In-Silico Study.

Phytate, also known as myoinositol hexakisphosphate, exhibits anti-nutritional properties and possesses a negative environmental impact. Phytase enzymes break down phytate, showing potential in various industries, necessitating thorough biochemical and computational characterizations. The present study focuses on Obesumbacterium proteus phytase (OPP), indicating its similarities with known phytases and its potential through computational analyses.

Metagenomic Analysis of Viromes of Mosquitoes across India.

Metagenomic analysis of and mosquitoes from diverse geographical regions of India revealed the presence of several insect viruses of human interest. Most abundant reads found in mosquitoes were of Phasi Charoen-like virus (PCLV), granulovirus (CfGV), Cell fusing agent virus (CFAV), and Wenzhou sobemo-like virus 4 (WSLV4), whereas WSLV4 and CfGV constituted the highest percentage of reads in viromes. Other reads that were of low percentage included Hubei mosquito virus 2 (HMV2), Porcine astrovirus 4 (PAstV4), and Wild Boar astrovirus (WBAstV).

Iridium(III)-catalyzed β-trifluoromethyl enone carbonyl-directed regioselective -C(sp)-H olefination.

Due to the lower LUMO energy level at the β-position of α,β-unsaturated-β-trifluoromethyl enone than that of its non-fluorinated counterpart, there is a challenge to activate the sp C-H bond of aromatic rings. Herein, we have reported iridium(III)-catalyzed β-trifluoromethyl enone carbonyl-directed regioselective aromatic C(sp)-H olefination with acrylates under oxidative conditions. Furthermore, coupling with natural product-derived acrylates, scale-up and product diversification have also been performed.

Aerobic Catalytic Cross-Dehydrogenative Coupling of Furans with Indoles Provides Access to Fluorophores with Large Stokes Shift.

Sustainability in chemical processes is a crucial aspect in contemporary chemistry with sustainable catalysis as a vital parameter of the same. There has been a renewed focus on utilizing earth-abundant metal catalysts to expand the repertoire of organic reactions. Furan is a versatile heterocycle of natural origin used for multiple applications.

Shared infection strategy of a fungal pathogen across diverse lineages of land plants, the Fusarium example.

Plants engage with a wide variety of microorganisms either in parasitic or mutualistic relationships, which have helped them to adapt to terrestrial ecosystems. Microbial interactions have driven plant evolution and led to the emergence of complex interaction outcomes via suppression of host defenses by evolving pathogens. The evolution of plant-microbe interactions is shaped by conserved host and pathogen gene modules and fast-paced lineage-specific adaptability which determines the interaction outcome.

Artificial Intelligence Applications for Biomedical Cancer Research: A Review.

Artificial intelligence (AI) has rapidly evolved and demonstrated its potential in transforming biomedical cancer research, offering innovative solutions for cancer diagnosis, treatment, and overall patient care. Over the past two decades, AI has played a pivotal role in revolutionizing various facets of cancer clinical research. In this comprehensive review, we delve into the diverse applications of AI across the cancer care continuum, encompassing radiodiagnosis, radiotherapy, chemotherapy, immunotherapy, targeted therapy, surgery, and nanotechnology.

Insights into the Potential Role of Plasmids in the Versatility of the Genus Pantoea.

In the past two decades, 25 different species of the genus Pantoea within the Enterobacteriaceae family, have been isolated from different environmental niches. These species have a wide range of biological roles. Versatility in functions and hosts indicate that this genus has undergone extensive genetic diversification, which can be attributed to the different extra-chromosomal genetic elements or plasmids found across this genus.

Various Extraction Techniques of Curcumin-A Comprehensive Review.

Curcumin, the active component of the rhizome of , is a safe substance whose applications are extensively used in medicinal, biological, pharmacological activities, and food cosmetic additives. In the field of medicine, curcuminoids have a greater impact; they have been associated with the suppression of neuropathic pain, depression, angiogenesis, tumorigenesis, diabetes, and diseases of the liver, skin, and pulmonary systems, as well as cardiovascular and nervous systems. These are in high demand and have high market potential and inflated costs.

Correlation of Ora Test and Caries Assessment Spectrum and Treatment Index (CAST) to Evaluate Caries Activity in 5-to-8-Year-Old Children.

Dental caries is a common chronic disease amongst children and are typically evaluated using the DMFT/deft index (decayed, missing, and filled teeth for permanent dentition/decayed, extracted, and filled teeth for primary dentition). To address the limitations associated with these indices, alternative assessment tools such as the Caries Assessment Spectrum and Treatment (CAST) index and Ora test have been developed. These methods aim to estimate caries activity within the oral cavity more accurately.

SDS-capped 1-pyrenecarboxaldehyde nanoprobe for selective detection of Cu ion from water samples: Spectroscopic approach.

Sodium dodecyl sulfate (SDS)-capped 1-pyrenecarboxaldehyde nanoparticles (PyalNPs) were prepared using a reprecipitation method in an aqueous medium and exhibited red-shifted aggregation-induced enhanced emission (AIEE). The dynamic light scattering (DLS) examination showed narrower particle size distribution with an average particle size of 41 nm, whereas -34.5 mV zeta potential value indicate the negative surface charge and good stability of nanoparticles (NPs) in an aqueous medium.

Synthesis of tetrazine-tetracyanobutadienes and their transformation into pyridazines inverse-electron demand Diels-Alder cycloaddition (IEDDA).

We report the synthesis of novel triphenylamine-tetrazine-tetracyanobutadiene based asymmetric and symmetric push-pull chromophores (1T and 1DT) by [2 + 2] cycloaddition-retroelectrocyclization of tetrazine connected electron-rich ethynyl triphenylamine with tetracyanoethene (TCNE). The electron-deficient tetrazine and tetracyanobutadiene (TCBD) moieties in 1T and 1DT create strong intramolecular charge transfer (ICT) interactions with TPA units, resulting in strong visible absorption with red edges reaching up to 700 nm (bandgaps of 1.79-1.

Pyridine C(sp)-H bond functionalization under transition-metal and rare earth metal catalysis.

Pyridine is a crucial heterocyclic scaffold that is widely found in organic chemistry, medicines, natural products, and functional materials. In spite of the discovery of several methods for the synthesis of functionalized pyridines or their integration into an organic molecule, new methodologies for the direct functionalization of pyridine scaffolds have been developed during the past two decades. In addition, transition-metal-catalyzed C-H functionalization and rare earth metal-catalyzed reactions have flourished over the past two decades in the development of functionalized organic molecules of concern.

Safety, immunogenecity and effectiveness of ChAdOx1 nCoV-19 vaccine during the second wave of pandemic in India: a real-world study.

Objectives: This real-world study was conducted to assess the adverse effects following immunization (AEFI) and immunogenicity of ChAdO×1 nCoV-19 vaccine in terms of neutralising antibody titers and to study the effects of covariates such as age, sex, comorbidities and prior COVID status on these outcomes. Also, the effectiveness of the vaccine based on interval between the two doses was also investigated.

Methods: A total of 512 participants (M/F=274/238) aged 35(18-87) years comprising a mixed population of healthcare workers, other frontline workers and general public were enrolled between March and May 2021.

Comparative Evaluation of the Remineralization Potential of Fluoride-containing Toothpaste, Honey Ginger Paste and Ozone. An Study.

Introduction: A drop in pH of the oral cavity results in demineralization, which, if continued, leads to loss of minerals from tooth structure, resulting in dental caries. A goal of modern dentistry is to manage noncavitated caries lesions noninvasively through remineralization in an attempt to prevent disease progression.

Materials And Methods: A total of 40 extracted premolar teeth were selected for the study.

Impacts of COVID-19-induced lockdown and key reforms in the Indian fisheries sector-a stakeholders' perspective.

The COVID-19 pandemic-induced lockdown has indisputably affected the aquaculture industry across the globe. India imposed a nationwide lockdown to contain the outbreak of COVID-19 that disrupted normalcy and economic activities. The fisheries sector was also highly affected.

Catalytic and Chemodivergent Synthesis of 1-Substituted 9-Pyrrolo[1,2-]indoles via Annulation of β-CF Enones with 3-Substituted Indoles.

Chemodivergent reactions are more advantageous in organic synthesis that yield diversely functionalized scaffolds from common starting materials. Herein, we report an efficient metal-free chemodivergent protocol for the synthesis of 1-substituted 9-pyrrolo[1,2-]indole derivatives in the presence of catalytic amounts of Lewis acid/Brønsted acid conditions using 3-substituted indoles and β-trifluoromethyl-α,β-unsaturated ketones. Fine-tuning of the catalyst and solvent system in the reaction conditions deliver the trifluoromethyl, trifluoroethylcarboxylate, or carboxylic acid substituents on the C1-position of 9-pyrrolo[1,2-]indole derivatives in situ.

Modulation of phenylpropanoid and lignin biosynthetic pathway is crucial for conferring resistance in pigeon pea against Fusarium wilt.

To elucidate the role of the phenylpropanoid pathway in the expression of resistance during compatible and incompatible interactions between pigeon pea and wilt-causing vascular pathogen Fusarium udum, we estimated the total phenol content, lignin, phenolic acids and activity of enzymes involved in lignin polymerization of monolignols and examined the expression pattern of lignin biosynthesis genes. Our results demonstrated a higher accumulation of free and cell wall-bound phenolics and total lignin content in the highly resistant pigeon pea genotype ICP 14623 as compared to susceptible genotype ICP 14166. An increased activity of phenylpropanoid pathway-associated defense enzymes such as Phenylalanine ammonia-lyase, polyphenol oxidase, ascorbate and guaiacol- dependent peroxidases in resistant pigeon pea genotypes suggests their role in resistance.