Inducible nitric oxide synthase promotes pathophysiological consequences of experimental bladder outlet obstruction.

Purpose: Bladder outlet obstruction leads to histological and functional changes in the bladder over time. We investigated the role of inducible nitric oxide synthase (iNOS) in the progression of pathological changes of the bladder secondary to outlet obstruction in a rat and a mouse model.

Materials And Methods: To assess expression of iNOS in the bladder, polymerase chain reaction amplification of mRNA was done.