Total Flavonoids in L. and Evaluation of Its Anticancer Activity.

To overcome the shortcomings of traditional extraction methods, such as long extraction time and low efficiency, and considering the low content and high complexity of total flavonoids in L., in this experiment, we adopted ultrasound-assisted enzymatic hydrolysis to improve the yield of total flavonoids, and combined this with molecular docking and network pharmacology to predict its core constituent targets, so as to evaluate its antitumor activity. The content of total flavonoids in L.

Chemical Constituents and Antitumor Mechanisms of Artemisia.

Background: At present, chemotherapy is still the main treatment for cancer, but its side effects and multidrug resistance limit the therapeutic efficacy. Natural products are the important sources for the development of antitumor drugs with higher efficiency and lower toxicity. Artemisia contains a variety of antitumor constituents, which can induce tumor cell apoptosis and cell cycle arrest, inhibit tumor angiogenesis, and accelerate iron ion-mediated oxidative damage.