Analysis of Cholera Risk in India: Insights from 2017-18 Serosurvey Data Integrated with Epidemiologic data and Societal Determinants from 2015-2019.

Background: Indian subcontinent being an important region in the fight to eliminate cholera needs better cholera surveillance. Current methods miss most infections, skewing disease burden estimates. Triangulating serosurvey data, clinical cases, and risk factors could reveal India's true cholera risk.

Dataset of geophysical electrical resistivity and subsurface profiling for natural resources exploration in a hard rock terrain of Tamil Nadu, India.

Geophysical resistivity technique; vertical electrical sounding (VES)/earth resistivity test (ERT) was carefully done at 35 locations in a hard rock terrain of Tamil Nadu, India to evaluate natural resources such as groundwater, economic mineral deposits, etc., Data acquisition was done by CRM-500 Aquameter along with GPS, topographic map, Brunton compass, measuring tape, field notebook, hammer, iron rods (electrodes), and batteries. Furthermore, the major four subsurface layers' thickness, resistivity, and pseudo-section profiles were identified from the resistivity dataset using IPI2WIN.

A Comparative analysis of PESC and PPSC copolyesters: Insights into viscosity, thermal behavior, crystallinity, and biodegradability.

The study examined various properties of synthesized copolyesters PESC and PPSC. Inherent viscosities of the copolyesters, measured in 1,4-dioxane at 32 °C, were 0.65 dL/g for PESC and 0.

Carbon nanoparticles fabricated microfilm: A potent filter for microplastics debased water.

Microplastics were found to be the major pollutant across the globe. Plastic microbeads, like 0.5 mm, are very small and mainly used for exfoliation.

Fate and transport of strontium in groundwater from a layered sedimentary aquifer system.

In this article, strontium distribution in sedimentary coastal aquifers of Eastern India was studied and its association with groundwater particles has been ascertained using hydrochemical and morphological tools. Groundwater contains Sr in the range of 0.08-4.

Ultrasonic assisted synthesis of RGO supported HoVO-ZnO nanocomposites, their enhanced photocatalytic activities and Rhodamine B degradation.

The RGO-supported HoVO-ZnO nanocomposite was synthesized using the ultra sonication process. X-ray diffraction patterns, Field emission scanning electron microscopy, high resolution transmission electron microscopy, Diffractive Reflectance spectroscopy, and photoluminescence spectroscopy were employed to examine the heterostructured photocatalyst in this research study. The photocatalytic efficiency of the RGO-supported HoVO-ZnO nanoparticles, under UV light irradiation, in the degradation of Rhodamine-B dye was investigated.

Arsenic distribution in sediments of multi-tier sedimentary formation of coastal Pondicherry, India - Implications on groundwater quality.

In this work, sediments collected from a 150-m deep litho-section of a coastal region and encompassing Quaternary, Tertiary and Cretaceous sedimentary formations were studied for arsenic distribution and other trace and redox sensitive elements. Arsenic concentration in the sediments is found to vary from <0.5 to 30 mg·kg and showed an increasing trend with the depth.

Seroprevalence of Dengue Infection Using IgG Capture ELISA in India, 2017-2018.

We conducted a nationally representative population-based survey in 60 districts from 15 Indian states covering all five geographic regions during 2017-2018 to estimate the age specific seroprevalence of dengue. Of the 12,300 sera collected, 4,955 were positive for IgG antibodies against dengue virus using IgG Indirect ELISA indicating past dengue infection. We tested 4,948 sera (seven had inadequate volume) positive for IgG antibodies on indirect ELISA using anti-dengue IgG capture ELISA to estimate the proportion of dengue infections with high antibody titers, suggestive of acute or recent secondary infection.

Exposure to mosquito coil and biomass fuel smoke and respiratory health in rural Tamil Nadu, India.

Background: Mosquito coil smoke, along with biomass fuel smoke, are sources of indoor air pollution. Biomass fuel smoke has been studied as a risk factor for poor respiratory outcomes. However, in an Indian context, few studies examine the effect of mosquito coil exposure on poor respiratory outcomes at the community level.

Does the morbidity management and disability prevention (MMDP) clinic serve the filarial lymphedema (FLE) patients' preeminent expectation?

Advocacy and training on "Home care" for filarial lymphoedma (FLE) patients are provided through morbidity management and disability prevention (MMDP) clinic commonly known as filariasis clinic and clinical improvement is assessed by follow-up visits. While the physicians aim at reducing the recurrent ADL (coined as ADLA in 1997) episodes, the patients expect reduction in LE volume. The objective of the present study was to know whether the MMDP clinic serves the primary expectation of the FLE patients.

Immunity against diphtheria among children aged 5-17 years in India, 2017-18: a cross-sectional, population-based serosurvey.

Background: Diphtheria is re-emerging as a public health problem in several Indian states. Most diphtheria cases are among children older than 5 years. In this study, we aimed to estimate age-specific immunity against diphtheria in children aged 5-17 years in India.

Hepatitis-B virus infection in India: Findings from a nationally representative serosurvey, 2017-18.

Introduction: India introduced a hepatitis-B (HB) vaccine in the Universal Immunization Program in 2002-2003 on a pilot basis, expanded to ten states in 2007-2008 (phase-1), and the entire country in 2011-2012 (phase-2). We tested sera from a nationally representative serosurvey conducted duing 2017, to estimate the seroprevalence of different markers of HB infection among children aged 5-17 years in India and to assess the impact of vaccination.

Methods: We tested sera from 8273 children for different markers of HB infection and estimated weighted age-group specific seroprevalence of children who were chronically infected (HBsAg and anti-HBc positive), and immune due to past infection (anti-HBc positive and HBsAg negative), and having serological evidence of HB vaccination (only anti-HBs positive).

Clinical Benefits of Supervised Home Care of the Morbidity Management and Disability Prevention Under National Filariasis Elimination Programme.

Mass drug administration and morbidity management and disability prevention (MMDP) though considered as two pillars of global program for elimination of filariasis, implementation of MMDP was disregarded in several endemic countries. Limb hygiene is the main component of MMDP and to address its overall clinical benefits, a community-based study was undertaken in three sets of populations. After obtaining written informed consent, clinical, quality of life (QoL) assessments were carried out and lymphedema volume was measured for three groups of lymphedema patients at intake, at 6, and 12 months follow-up.

Burden of dengue infection in India, 2017: a cross-sectional population based serosurvey.

Background: The burden of dengue virus (DENV) infection across geographical regions of India is poorly quantified. We estimated the age-specific seroprevalence, force of infection, and number of infections in India.

Methods: We did a community-based survey in 240 clusters (118 rural, 122 urban), selected from 60 districts of 15 Indian states from five geographical regions.

High prevalence of soil-transmitted helminth infections among primary school children, Uttar Pradesh, India, 2015.

Background: Soil-transmitted helminth (STH) infections often affect the poorest and most deprived communities. In order to generate reliable data for planning a school based deworming program, we conducted a survey among primary school children studying in government schools in the Indian state of Uttar Pradesh. The objectives of our survey were to estimate the prevalence and intensity of STH infections.

Coverage of childhood vaccination among children aged 12-23 months, Tamil Nadu, 2015, India.

Background & Objectives: District-Level Household Survey-4 (DLHS-4) indicated that during 2012-2013, only 56 per cent of children aged 12-23 months in Tamil Nadu were fully vaccinated, which were lesser than those reported in earlier national surveys. We, therefore, conducted cluster surveys to estimate coverage of childhood vaccination in the State, and also to identify the factors associated with low coverage.

Methods: Cross-sectional surveys were conducted in 15 strata [municipal corporation non-slum (n=1), municipal corporation slum (n=1), hilly (n=1), rural (n=6) and urban (n=6)].

Development of a Scalable Process for the Synthesis of DNDI-VL-2098: A Potential Preclinical Drug Candidate for the Treatment of Visceral Leishmaniasis.

A process suitable for kilogram-scale synthesis of (2)-2-methyl-6-nitro-2-{[4-(trifluoromethoxy)phenoxy]methyl}-2,3-dihydroimidazo[2,1-][1,3]oxazole (DNDI-VL-2098, ), a preclinical drug candidate for the treatment of visceral leishmaniasis, is described. The four-step synthesis of the target compound involves the Sharpless asymmetric epoxidation of 2-methyl-2-propen-1-ol, . Identification of a suitable synthetic route using retrosynthetic analysis and development of a scalable process to access several kilograms of are illustrated.

Risk Factors for Chronic Intertrigo of the Lymphedema Leg in Southern India: A Case-Control Study.

Rich clinical experiences indicate that toe web intertrigo is a major predisposing condition for cellulitis/acute dermatolymphango adenitis (ADLA) and the number of lesions is the strongest predictor of frequency of ADLA in lymphedema (LE) patients. However, there is scanty information on the risk factors for the establishment of chronic toe web intertrigo in LE patients. We performed a case-control study recruiting 52 lower limb LE with intertrigo and 52 lower limb LE without intertrigo in community settings and assessed general and local potential risk factors for chronic intertrigo.

DNA nanostructures based biosensor for the determination of aromatic compounds.

Graphite electrode was modified using multi-walled carbon nanotubes (MWCNT), chitosan (CS), glutaraldehyde (GTA) and DNA nanostructures (nsDNA). DNA nanostructures of 50 nm in size were produced from single DNA template sequence using a simple two step procedure and were confirmed using TEM and AFM analysis. The modified electrode was applied to the electrochemical detection of aromatic compounds using EIS.

Vermicomposting of Solid Waste Using Local and Exotic Earthworms: A Comparative Study.

The aim of this study was to assess the decomposition efficiency of earthworms, local (L.mauritii) as well as exotic (Eisenia foetida) in vermicomposting of garden litter in SRM University campus. The vermicompost produced through vermicomposting of garden litter mixed with cow dung in the ratio of 3:1 by using local and exotic earthworms (Eisenia foetida) was rich in ammoniacal nitrogen, nitrate nitrogen, available phosphorus, total potassium and TKN, and there was a reduction in total organic carbon and carbon to nitrogen ratio.

Measles case fatality rate in Bihar, India, 2011-12.

Background: Updated estimates of measles case fatality rates (CFR) are critical for monitoring progress towards measles elimination goals. India accounted for 36% of total measles deaths occurred globally in 2011. We conducted a retrospective cohort study to estimate measles CFR and identify the risk factors for measles death in Bihar-one of the north Indian states historically known for its low vaccination coverage.

Nonisothermal kinetics analysis of the dehydration of ziprasidone hydrochloride monohydrate by thermogravimetry.

In the current work the kinetics of dehydration of ziprasidone hydrochloride monohydrate was studied by nonisothermal thermogravimetry. Ziprasidone hydrochloride monohydrate was heated from 30 to 150° with a heating rate of 5° per min under nitrogen gas atmosphere and weight loss data were collected. Powder X-ray difraction was used to characterize the solid before and after dehydration.