Vasorelaxant-Mediated Antihypertensive Effect of the Leaf Aqueous Extract from (Dillon & A. Rich) Walp (Menispermaceae) in Rat.

is a medicinal plant used in Cameroon alternative medicine to treat arterial hypertension (AHT). Previous studies demonstrated the endothelium nitric oxide-independent vasorelaxant property of the aqueous extract from (AESA). But its effect on AHT is unknown.

Antihypernociceptive effects of Petersianthus macrocarpus stem bark on neuropathic pain induced by chronic constriction injury in rats.

Petersianthus macrocarpus (Lecythidaceae) stem bark is traditionally used in West and Central Africa for the treatment of boils and pain. The present study examined the chemical composition of the aqueous and methanolic stem bark extracts of P. macrocarpus by liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) .

Glucose, lipid and oxidative stress lowering activity of the aqueous extract from leafy stems of Gilg & Brandt in dexamethasone-induced hyperglycemia in rats.

Background: Diabetes mellitus is a metabolic disorder characterised by chronic hyperglycemia. The present research work aimed to evaluate the hypoglycaemic, hypolipidemic and antioxidant effects of leafy stems of Gilg & Brandt in insulin resistant rats.

Methods: The oral glucose tolerance test (OGTT) was performed in normal rats.

Hypoglycemic, antidyslipidemic and antioxydant effects of barks extract on high-fat diet and streptozotocin-induced type 2 diabetes rats.

Backgroud: is a plant belonging to the Sapotaceae family and used in traditional medicine in the treatment of diabetes mellitus. The aim of this work was to evaluate the hypoglycemic, antidyslipidemic and antioxidant effects of on type 2 diabetic rats.

Methods: To induce type 2 diabetes mellitus (T2DM), animals were fed a high-fat diet for 4 weeks followed by an intraperitoneal injection of 35 mg/kg of streptozotocin.

Glucose-lowering potential of roots in a diabetic rat model.

Objective: is distributed in the Sudano-Sahelian zone and used traditionally for the treatment of diabetes. This study was designed to assess the hypoglycemic effects of in Wistar diabetic rats.

Materials And Methods: Phytochemical analysis was carried out on aqueous and methanolic extracts of .

Anti-androgenic, anti-oxidant and anti-apoptotic effects of the aqueous and methanol extracts of Pterorhachis zenkeri (Meliaceae): Evidence from in vivo and in vitro studies.

The aim of this study was to evaluate the effects of Pterorhachis zenkeri (Meliaceae) on sex organ growth in immature male rats and, oxidative stress and apoptosis markers in CCL-97 (R2C) Leydig cells. For the in vivo studies, 70 immature male Wistar rats (n = 10/group) were treated for 2 or 4 weeks with: distilled water (10 ml/kg, per os) plus soya oil (1 ml/kg, sc), bicalutamide (10 mg/kg, per os), aqueous or methanol extract of P. zenkeri (10 mg/kg or 62 mg/kg, per os) or testosterone propionate (3 mg/kg, sc).

Immunomodulatory Activity of L. (Cucurbitaceae) Leaf Diethyl Ether and Methanol Extracts on -Infected Mice and LPS-Induced Phagocytic Activities of Macrophages and Neutrophils.

Infections due to strains constitute one of the major health problems in humans, particularly in Africa. The use of traditional herbs has proven effective in reducing the incidence of infection in some high-risk groups. To assess the effects of leaf extracts that influence blood infection, an study of the effect on macrophages and neutrophils and treatment of mouse model of infection was done.

Chronic oral safety study of the aqueous extract of Combretum molle twigs on biochemical, haematological and antioxidant parameters of Wistar rats.

Background: Combretum molle R.B/G. Don (Combretaceae) is a graceful deciduous shrub, distributed especially in tropical Africa and used in traditional medicine in the treatment of malaria, diabetes, and bacterial, liver and cardiovascular deseases.

Colibri® insecticide induces male reproductive toxicity: alleviating effects of (Anacardiaceae) in rats.

Background: Imidacloprid, a neonicotinoid insecticide, has been associated to severe reproductive toxicity in mammals. Although some preventive measures have been reported, curative strategies are yet to be explored. The present study was designed to investigate the alleviating effects of on the reproductive toxicity of colibri®, a commercial formulation of imidacloprid, in adult male rats.

Antioxidant Properties and Digestive Enzyme Inhibitory Activity of the Aqueous Extract from Leafy Stems of .

(Vitaceae) is a plant used in Cameroonian traditional medicine for the treatment of diabetes. The aims of this study were to evaluate the in vitro antioxidant and antidiabetic activities of the aqueous extract of leafy stems. The enzyme inhibitory activity was determined in vitro on -amylase and -glucosidase enzymes, followed by confirmative study in vivo on normal rats (oral starch and sucrose tolerance tests at doses of 111, 222, and 444 mg/kg).

Protective Effects of Aqueous Extract of Stem Bark on Dexamethasone-Induced Insulin Resistance in Rats.

The aim of this study was to evaluate the effects of the aqueous extract of stem bark on dexamethasone-induced insulin resistance in rats. A quantitative phytochemical study was done on the aqueous extract of for the total phenol, flavonoid, and flavonol determination. Insulin resistance was induced by intraperitoneal injection of dexamethasone (1 mg/kg) for 8 days, one hour before oral administration of different treatments (extract at doses of 60, 120, and 240 mg/kg and metformin at 40 mg/kg).

Cytoarchitectural improvement in Leydig cells of diabetic rats after treatment with aqueous and ethanol extracts of (Dracaenaceae).

Background And Aim: Recent studies have demonstrated the androgenic effects of in castrated and diabetic rats, but the cytoarchitectural mechanism at the level of Leydig cells (LCs) justifying this improvement in androgens production in diabetic rats has never been examined. We investigated the effects of aqueous and ethanol extracts of on diabetes-induced cytoarchitectural impairments of LCs in rats.

Experimental Procedure: Besides a normal group, 4 groups of diabetic rats were treated orally with Millipore water (10 ml/kg, diabetic), sildenafil citrate (1.

Aphrodisiac property of aqueous and methanolic extracts of (Arecaceae) in sexually experienced male rats.

Background: (Arecaceae) is a medicinal plant commonly used as a sexual enhancer.

Objective: To investigate the aphrodisiac potential of aqueous extract (AE) and methanolic extract (ME) of in sexually experienced male rats.

Materials And Methods: Thirty male Wistar rats were randomly distributed into six groups (5 rats per group) and administered for 14 days with distilled water (10 ml/kg), sildenafil citrate (1.

Cyclophosphamide-induced reproductive toxicity: Beneficial effects of Helichrysum odoratissimum (Asteraceae) in male Wistar rats.

Objective: Cyclophosphamide (CP) is commonly used to treat some cancers, but its clinical efficacy is also linked with testicular toxicity. We investigated the effects of aqueous extract (AE) and methanolic extract (ME) of Helichrysum odoratissimum for reducing CP-induced reproductive toxicity in male rats.

Methods: In addition to a normal control (group 1), drugs or vehicles were administered orally to seven groups (n = 5) of rats that had already received 4-weeks of pre-treatment with CP (5 mg/[kg·d], per oral administration); group 2 received CP + distilled water (10 mL/[kg·d]); group 3 received CP + 5% tween 80 (10 mL/[kg·d]); group 4 received CP + clomiphene citrate (0.

Aqueous and ethanol extracts of Dracaena arborea (Wild) Link (Dracaenaceae) alleviate reproductive complications of diabetes mellitus in rats.

Reproductive dysfunction is one of the most prevalent diabetes complications. Draceana arborea is known to enhance sexual function in diabetic rats, but the underlying mechanisms have not been thoroughly elucidated. This study examined the effects of D.

Sexual stimulant effects of the mixture of Mondia whitei, Dracaena arborea, and Bridelia ferruginea in normal and prediabetic male Wistar rats.

Background We investigated the effects of a polyherbal formulation prepared from the extracts of Mondia whitei (Periplocaceae), Dracaena arborea (Dracaenaceae), and Bridelia ferruginea (Euphorbiaceae) (MDB) on the sexual behavior of normal rats (NR) and prediabetic rats (PR). Methods Male Wistar rats were administered with drinking fructose solution (21%) or tap water for 16 weeks. After induction of prediabetic status, NR (n = 30) and PR (n = 30) were randomly distributed into 10 groups of six animals each and orally treated with distilled water (10 mL/kg), sildenafil citrate (5 mg/kg), or MDB (50, 100, or 500 mg/kg) for 21 days.

(Euphorbiaceae) Restores Ovarian Functions in Letrozole-Induced Polycystic Ovarian Syndrome in Rats.

Polycystic ovarian syndrome (PCOS) is one of the common causes or female infertility. (Euphorbiaceae) is a plant used to treat various ailments including frequent menstruation and anovulation. We investigated the effects of extracts on estrus cyclicity, lipid profile, oxidative stress-related markers, sex hormones, and ovarian architecture in letrozole-induced PCOS in rats.

Curative effects of Distemonanthus benthamianus Baillon. Trunk-bark extracts on enteropathogenic Escherichia coli 31-induced diarrhea in rats.

Background Distemonanthus benthamianus is used in the Western part of Cameroon to treat diarrheal episodes and infections. This study assessed its trunk-bark extracts activity against enteropathogenic Escherichia coli 31 (EPEC 31)-induced diarrhea in rats. Methods Aqueous and methanolic extracts were analyzed through high-performance liquid chromatography (HPLC).

Aframomum melegueta prevents the ejaculatory complications of propylthiouracil-induced hypothyroidism in sexually experienced male rats: Evidence from intravaginal and fictive ejaculations.

Objective: Hypothyroidism has been claimed to generate sexual dysfunctions such as ejaculatory disorders. Aframomum melegueta is an aphrodisiac plant with pro-ejaculatory properties. We investigated the protective effects of aqueous extract (AE) and methanolic extract (ME) of A.

Preventive effects of Aframomum melegueta extracts on the reproductive complications of propylthiouracil-induced hypothyroidism in male rat.

Recent studies have demonstrated that hypothyroidism is associated with infertility. This work was undertaken to evaluate the protective effects of Aframomum melegueta on testicular functions and fertility of hypothyroid male rats. Male rats were orally treated with propylthiouracil (PTU: 10 mg/kg) in combination with plant aqueous or methanol seed extract (20 and 100 mg/kg) for 56 days.

The aqueous and methanol extracts of Bambusa vulgaris (Poaceae) improve calcium and phosphorus levels, and bone microstructure in ovariectomized model of osteoporosis.

Background Osteoporosis represents the most common metabolic bone disease. Bambusa vulgaris (Poaceae) is a plant with potential antiosteoporotic effects, due to its phytoestrogenic, antioxidative, and anti-inflammatory properties. This study was undertaken to evaluate the effects of aqueous and methanol extracts of B.

Antidiabetic properties of aqueous and methanol extracts from the trunk bark of Ceiba pentandra in type 2 diabetic rat.

The type 2 diabetes is one of the major global health issues that affects millions of people. This study evaluated the antidiabetic activity of aqueous extracts (AECP) and methanol extracts (MECP) from Ceiba pentandra trunk bark on an experimental model of type 2 diabetes (T2D). This model was induced in rats by the combination of a high-fat diet (HFD) and a single dose of streptozotocin (40 mg/kg, intraperitoneal) at the seventh day of experimentation.

Leaf-Methanolic Extract of (Araliaceae) (L. F. Phillipson) Reverses Amitriptyline-Induced Sexual Dysfunction in Male Rats.

The people of the Bayangi tribe (Manyu Division) of Cameroon have used the leaves of (Araliaceae) traditionally for decades as an aphrodisiac. In order to scientifically investigate this folk claim, we evaluated the effects of the leaf-aqueous extract of on the sexual behavior of normal male rats. The present study was designed to assess the effects of the leaf-methanolic extract of on amitriptyline-induced sexual dysfunction in male rats.

Hypoglycemic Properties of the Aqueous Extract from the Stem Bark of in Dexamethasone-Induced Insulin Resistant Rats.

Parts of are wildly used in Africa to treat diabetes and previous works have demonstrated their antidiabetic effects on type 1 diabetes models. In addition, it has been recently shown that the decoction and the methanol extract from the stem bark of potentiate the peripheral glucose consumption by the liver and skeletal muscle slices. But nothing is known about its effect on type II diabetes, especially on insulin resistance condition.

Screening of the immunomodulatory and antibacterial activity of Termitomyces letestui (Pat.) Heim (Lyophyllaceae), an edible mushroom from Cameroon.

Background Globally, Termitomyces letestui is used by different communities to treat various illnesses, including bacterial infection, although with limited scientific evidence. The current study aims to assess the immunomodulatory and antibacterial properties of the water extract of a wild mushroom, T. letestui in mice model.