NUMB alternative splicing and isoform specific functions in development and disease.

The NUMB gene encodes a conserved adaptor protein with roles in asymmetric cell division and cell fate determination. First described as an inhibitor of Notch signaling, multi-functional NUMB proteins regulate multiple cellular pathways through protein complexes with ubiquitin ligases, polarity proteins and the endocytic machinery. The vertebrate NUMB protein isoforms were identified over two decades ago, yet the majority of functional studies exploring NUMB function in endocytosis, cell migration and adhesion, development and disease have largely neglected the potential for distinct isoform activity in design and interpretation.

Remote Sensing Imagery Data Analysis Using Marine Predators Algorithm with Deep Learning for Food Crop Classification.

Recently, the usage of remote sensing (RS) data attained from unmanned aerial vehicles (UAV) or satellite imagery has become increasingly popular for crop classification processes, namely soil classification, crop mapping, or yield prediction. Food crop classification using RS images (RSI) is a significant application of RS technology in agriculture. It involves the use of satellite or aerial imagery to identify and classify different types of food crops grown in a specific area.

PAPR reduction using SLM-PTS-CT hybrid PAPR method for optical NOMA waveform.

In this article, we focus on optimising the SLM-PTS-CT (selective mapping, partial transmission sequence, circular transformation) hybrid method for optical non-orthogonal multiple access (O-NOMA) waveforms. The goal is to enhance the spectrum performance and practicality of O-NOMA systems while mitigating the PAPR issue through a hybrid approach. The SLM-PTS-CT hybrid method is applicable to O-NOMA waveforms, providing effective PAPR reduction.

Numb exon 9 inclusion regulates Integrinβ5 surface expression and promotes breast cancer metastasis.

The endocytic adaptor protein Numb acts as a tumor suppressor through downregulation of oncogenic pathways in multiple cancer types. The identification of splicing alterations giving rise to changes in Numb protein isoform expression indicate that Numb also has tumor promoting activity, though the underlying mechanisms are unknown. Here we report that NUMB exon 9 inclusion, which results in production of a protein isoform with an additional 49 amino acids, is a feature of multiple cancer types including all subtypes of breast cancer and correlates with worse progression-free survival.

Sequential Localizing and Mapping: A Navigation Strategy via Enhanced Subsumption Architecture.

In this paper, we present a navigation strategy exclusively designed for social robots with limited sensors for applications in homes. The overall system integrates a reactive design based on subsumption architecture and a knowledge system with learning capabilities. The component of the system includes several modules, such as doorway detection and room localization via convolutional neural network (CNN), avoiding obstacles via reinforcement learning, passing the doorway via Canny edge's detection, building an abstract map called a Directional Semantic Topological Map (DST-Map) within the knowledge system, and other predefined layers within the subsumption architecture.

A Doorway Detection and Direction (3Ds) System for Social Robots via a Monocular Camera.

In this paper, we propose a novel algorithm to detect a door and its orientation in indoor settings from the view of a social robot equipped with only a monocular camera. The challenge is to achieve this goal with only a 2D image from a monocular camera. The proposed system is designed through the integration of several modules, each of which serves a special purpose.