Publications by authors named "Kamal Khorfan"
Article Synopsis
- The link between androgens and liver cancer has been recognized since 1975, but documented cases in patients using androgens are rare.
- This text presents three cases of patients who developed liver (HCC) and bile duct cancers while undergoing anabolic androgenic steroid (AAS) therapy and testosterone supplementation.
- It also reviews existing literature on how androgens may contribute to the malignant transformation of liver and bile duct tumors.
Dissecting novel mechanisms of hepatitis B virus related hepatocellular carcinoma using meta-analysis of public data.
World J Gastrointest Oncol
September 2022
Article Synopsis
- Hepatitis B virus (HBV) can lead to liver cancer (hepatocellular carcinoma) through oncogenic processes, not just cirrhosis, highlighting the need to identify specific genes and pathways involved.
- The study aims to better understand how HBV contributes to liver cancer and to find potential therapeutic targets using a meta-analysis of tumor and adjacent non-tumor samples.
- Key findings include the identification of RABL6 and HOXA10 as significant regulators in HBV-related liver cancer, with RABL6 linked to increased mortality and HOXA10 implicated in tumor growth through mechanisms like downregulation of tumor suppressors.
Background: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the United States and globally. The currently understood model of pathogenesis consists of a 'multiple hit' hypothesis in which environmental and genetic factors contribute to hepatic inflammation and injury.
Aim: To examine the genetic expression of NAFLD and non-alcoholic steatohepatitis (NASH) tissue samples to identify common pathways that contribute to NAFLD and NASH pathogenesis.
Background And Aim: Hepatitis C is a leading cause of chronic liver disease and hepatocellular carcinoma (HCC). Understanding the evolution and biology of HCC among HCV patients may lead to novel therapeutic avenues and risk stratification.
Material And Methods: Using meta-analysis platform STARGEO, we performed two separate meta-analyses as follows: 357 HCV-related HCC tumor samples with 220 adjacent non-tumor samples and 92 HCV-related cirrhotic liver samples with 53 healthy liver samples as a control.