Exploring the nutritional composition and quality parameters of natural honey from diverse melliferous flora.

Natural honey is enriched with essential and beneficial nutrients. This study aimed to investigate the melliferous flora microscopic techniques and assess the biochemical properties of honey. Flavonoid and phenolic contents in honey samples were analyzed via colorimetric and Folin-Ciocalteu methods and the alpha-amylase, reducing power, and minerals using Pull's and spectroscopy methods.

Spatio-temporal dynamics and risk cluster analysis of highly pathogenic avian influenza (H5N1) in poultry: Advancing outbreak management through customized regional strategies in Egypt.

Background: Highly pathogenic avian influenza (HPAI) (H5N1) has been endemic in Egypt for almost two decades, profoundly impacting both the poultry industry and public health. Egypt stands as a prominent epicenter for HPAI H5N1 outbreaks in Africa, marked by the highest number of positive human cases. Despite continuous governmental efforts, prior research underscored the inadequacy of strategies in controlling the virus spread.

Unveiling the impact of pipe materials on water hammer in pressure pipelines: an experimental and numerical study.

Water hammer (WH) is a phenomenon characterized by the rapid opening or closing of valves or pumps in pipelines, resulting in a disruptive noise, intense vibrations, and potential damage to pipes, fittings, structures, and even human safety. While WH arresters are commonly employed to mitigate this issue in smaller plumbing systems, alternative solutions are required for larger applications like power plants. Researchers have proposed the utilization of pipe materials with a low modulus of elasticity in areas prone to WH events, as these materials possess the capability to absorb a significant portion of the resulting vibrations.

Mechanical properties of two-dimensional material-based thin films: a comprehensive review.

Two-dimensional (2D) materials are materials with a thickness of one or a few atoms with intriguing electrical, chemical, optical, electrochemical, and mechanical properties. Therefore, they are deemed candidates for ubiquitous engineering applications. Films and three-dimensional (3D) structures made from 2D materials introduce a distinct assembly structure that imparts the inherent properties of pristine 2D materials on a macroscopic scale.

Utilizing urban and agricultural waste for sustainable production of mesoporous hybrid nanocomposites in synthetic dye removal and antimicrobial activity.

The discharge of untreated dye waste from various industrial sectors into wastewater poses significant environmental and health risks. This study presents an innovative approach by developing a cost-effective and eco-friendly hybrid mesoporous nanocomposite, silver nanoparticles@mesoporous mango peel-derived carbon (AgNPs@MMC), synthesized from agricultural waste (mango peels) and urban waste (X-ray film waste). The core objectives of this work are: (i) recycling agricultural and urban waste to produce valuable materials; (ii) achieving effective removal of methyl violet 10B (MV10B) through simultaneous adsorption and photocatalytic degradation; and (iii) evaluating the antimicrobial properties of the developed material.

The gut microbiome across the lifespan: how diet modulates our microbial ecosystem from infancy to the elderly.

This comprehensive review examines the impact of dietary patterns on gut microbiome composition and diversity from infancy to old age, linking these changes to age-related health outcomes. It investigates how the gut microbiome develops and changes across life stages, focusing on the influence of dietary factors. The review explores how early-life feeding practices, including breastfeeding and formula feeding, shape the infant gut microbiota and have lasting effects.

The range and variation in serum estradiol concentration in perimenopausal and postmenopausal women treated with transdermal estradiol in a real-world setting: a cross-sectional study.

Objectives: The aims of the study are to explore the range and variation in serum estradiol concentration, and to estimate the prevalence of "poor absorption" (women using licensed estradiol doses with subtherapeutic levels), in perimenopausal and postmenopausal women using transdermal estradiol in the real world.

Methods: This is a cross-sectional analysis in a specialist menopause clinic in the UK.

Results: Serum samples were obtained from 1,508 perimenopausal and postmenopausal women.

There Is Significant Within-Subject Variation in the Time from Light Stimulus to Maximum Pupil Constriction Among Healthy Controls.

: Handheld quantitative pupilometers (QPs) measure each phase of the pupillary light reflex (PLR) and provide a summary score based on these values. One phase of the PLR is the period of time from the onset of light exposure to the maximum constriction of the pupil, also known as time to maximum constriction (tMC). Although tMC has been found to vary significantly among patients with neurological injury, there are no studies reporting tMC in healthy controls.

Post-Traumatic Stress in Mothers of Children Having Complex Cardiac Surgery Early in Life.

To determine: (i) frequency of probable post-traumatic stress disorder (PTSD) in mothers of infants after complex cardiac surgery (CCS), (ii) predictors of probable PTSD, and (iii) impact on child neurodevelopment. The Impact of Event Scale-Revised (IES-R) was administered to 60 mothers of infants ≥ 6 months after CCS at ≤ 6 weeks of age. The IES-R measures response to a specific traumatic event: Scores < 24, no concern; 24-32, clinical concern; and ≥ 33, probable diagnosis of PTSD.

Time series patterns of dengue and associated climate variables in Bangladesh and Singapore (2000-2020): a comparative study of statistical models to forecast dengue cases.

This study explores the effect of climate factors on dengue incidence in Bangladesh and Singapore from 2000 to 2020. Various forecasting models, including Seasonal ARIMA, Poisson regression, artificial neural networks (ANN), support vector machines (SVM), and other statistical techniques, were applied to forecast dengue trends and generate future datasets. The results showed that Bangladesh has higher mean temperatures.

Small cell lung cancer presenting with pleural effusion and superior vena cava obstruction.

Small cell lung cancer with concurrent pleural effusion and superior vena cava obstruction is a rare presentation with high risk of respiratory and circulatory compromise warranting prompt and multidisciplinary treatment.

Value of miR200b and its combination with other biochemical markers in the diagnosis of epithelial ovarian cancer.

Objective: This study aimed to analyse the diagnostic performance of miR200b in epithelial ovarian cancer (EOC) in a group of Egyptian patients and to evaluate the combined use of miR200b with other biomarkers as a reliable diagnostic and prognostic indicator of EOC.

Methods: We tested the expression of cell-free miR200b in 30 EOC patients before undergoing optimum cytoreductive surgery, 19 females with benign ovarian disease and 14 normal healthy females using quantitative real time PCR. All cases were tested for CA125, HE4 and CRP.

Decoding the synergy: unveiling gradient boosting regression model for multivariate quantitation of pioglitazone, alogliptin and glimepiride in pure and tablet dosage forms.

This study represents a comparison among the performances of four multivariate procedures: partial least square (PLS) and artificial neural networks (ANN) in addition to support vector regression (SVR) and extreme gradient boosting (XG Boost) algorithm for the determination of the anti-diabetic mixture of pioglitazone (PIO), alogliptin (ALG) and glimepiride (GLM) in pharmaceutical formulations with aid of UV spectrometry. Key wavelengths were selected using knowledge-based variable selection and various preprocessing methods (e.g.

Reliability of neutrophil gelatinase-associated lipocalin in detecting acute tubular necrosis in decompensated cirrhosis: Systematic review and meta-analysis.

Background: Acute kidney injury (AKI) in cirrhosis is common. The diagnosis of AKI in cirrhosis patients depends on clinical presentation and laboratory tests like serum creatinine. However, urine biomarkers could also be used to assess the type of AKI and the severity of the disease.

Does intracranial pressure vary based on external ventricular drainage? A real-world clinical observation study.

Background: External ventricular drains (EVDs) are placed in patients with increased intracranial pressure (ICP) to serve as a cerebrospinal fluid (CSF) pressure flow diverter and ICP monitor. EVD management practice among institutions and practitioners varies greatly, with little evidence supporting ideal ICP recording and CSF drainage practice.

Objective: This study's aim is to determine variations in ICP across 21 min before and after CSF drainage.

Intervening Effect of Maladaptive Personality on the Relationship Between Defense Styles and Psychiatric Symptoms Among Prisoners.

Background: Prison settings are stress-inducing environments that make individuals more vulnerable to psychopathology. Defense styles and personality traits have long been associated with psychopathology. The current study aimed to explain the intervening role of maladaptive personality domains on the relationship between defense styles and psychiatric symptoms among male convicts imprisoned in nine Central Jails of Punjab, Pakistan.

Pulmonary metastasis of giant cell tumour of tibia.

Giant cell tumour of the tibia with pulmonary metastasis is very rare and the malignancy usually appears several years after the initial lesion. Imaging at the earliest instance is highly beneficial since surgical resection to remove the metastases raises survival rates; therefore, relentless follow-up in GCT is vital.

Design, synthesis, and cytotoxicity screening of novel pyrazolopyrimidines over renal cell carcinoma (UO-31 cells) as p38α inhibitors, and apoptotic cells inducing activities.

A series of novel molecules with pyrazolopyrimidine-4-amine core were designed and synthesized as potential cytotoxic agents over Renal Cell Carcinoma cells (UO-31). Results of cytotoxic activity against UO-31 cells showed that pyrazolopyrimidines 19 and 31 were found to be more cytotoxic than sorafenib (SOR). The cytotoxic activity of these compounds appeared to correlate with their ability to inhibit p38α MAPK which are 2.

Analysis of Heavy Metal Pollution in the Water of the Halda River: A Distinctive Breeding Habitat for Carp Fish in Bangladesh.

Background: The present study aimed to assess the heavy metal concentrations in water from different sampling sites of the Halda River, the only natural breeding ground of Indian major carps.

Objectives: We have analysed the contamination level and seasonal variations of heavy metals (viz. Fe, Cu, Zn, Cr, Cd and Pb).

Metabolomics reveals a differential attitude in phytochemical profile of black tea ( Var. ) during processing.

Black tea's quality and flavor are largely influenced by its processing stages, which affect its volatile and non-volatile phytochemicals. This study aimed to optimized black tea manufacturing by investigating withering time, fermentation time, and temperature's impact on sensory quality. Using a U* (15) uniform design, optimal conditions were determined: 14 h of withering, 5.

Tobacco smoke exposure is a driver of altered oxidative stress response and immunity in head and neck cancer.

Purpose: Exposomes are critical drivers of carcinogenesis. However, how they modulate tumor behavior remains unclear. Extensive clinical data link cigarette smoke as a key exposome that promotes aggressive tumors, higher rates of metastasis, reduced response to chemoradiotherapy, and suppressed anti-tumor immunity.

Left Atrial Appendage Occlusion During Cardiac Surgery to Prevent Stroke: A Systematic Review and Meta-Analysis.

Atrial fibrillation accounts for 1/6 of all strokes, potentially leading to significant disability and death. The left atrial appendage (LAA) is the primary location for thrombus formation. Excluding the LAA has been hypothesized to decrease the risk of ischemic stroke.

Rare case of massive inguinal dermatofibrosarcoma protuberans: A case report.

DFSP is a cutaneous soft tissue sarcoma. A 35 year old male patient presented with DFSP in the inguinal region which is a rare soft tissue sarcoma which usually presents in the torso, occurring very rarely in the inguinal region. Hence in case of any swelling in the inguinal region, DFSP should be in differential diagnosis.