Site-Selective Synthesis of C-17 Ester Derivatives of Natural Andrographolide for Evaluation as a Potential Anticancer Agent.

A library of 57 compounds of natural andrographolide was designed, synthesized, and screened for studies against four human cancer cell lines: A594, PC-3, MCF-7, and HCT-116. Most of the synthesized compounds displayed better cytotoxic profile against all tested cells compared to the parent andrographolide (). The tested semisynthetic derivatives of andrographolide were found to be more sensitive toward lung carcinoma (A594) and prostate carcinoma (PC-3) cell lines.

Tellurophene-Containing Core-Modified Pentaphyrin(2.1.1.1.1)s.

Various core-modified tellurophene-containing pentaphyrin(2.1.1.

Switching of Aromatic Free Base Triphyrin(2.1.1) to Antiaromatic Phosphorus(V) Complexes of Triphyrin(2.1.1).

The aromatic 14π -tetraaryl triphyrin(2.1.1)s were switched to stable antiaromatic 16π P(V) complexes of triphyrin(2.

Core-Modified Pentaphyrins(2.1.1.1.1) and Bis(difluoroborane) Complex: Synthesis, Structure, and Spectral and Redox Properties.

A series of hetero analogues of pentaphyrins(2.1.1.

Covalently linked meso-tetraaryl triphyrin(2.1.1)-ferrocene(s) conjugates: synthesis and properties.

Functionalized meso-tetraaryl triphyrins(2.1.1) containing two meso-iodophenyl groups or a bromo group at the β-pyrrole carbon were synthesized over a sequence of steps.

Synthesis of meso-Tetraaryl Triphyrins(2.1.1).

A simple, straightforward [2+1] condensation of 5,6-diaryldipyrroethene dicarbinols with pyrrole under mild acid-catalyzed conditions resulted in the formation of highly desirable aromatic β-free meso-tetraaryl [14]triphyrins(2.1.1) in 15-18% yields.