Novel reducible linear L-lysine-modified copolymers as efficient nonviral vectors.

The development of biodegradable gene delivery systems with high transfection efficiencies is paramount to the clinical translation of nonviral gene carriers. Therefore, to produce a biocompatible, reducible, effective and non-toxic gene delivery system, we have designed and synthesized novel reducible linear L-lysine modified copolymers (LLCs) as an alternative to high molecular weight poly(L-lysine) (PLL). The molecular weight (MW) of the copolymers was found to be approximately 3.