Publications by authors named "Kalyani Kottilil"
Coronary artery disease (CAD) and peripheral artery disease (PAD) are common and dangerous conditions that are both driven by atherosclerosis. Despite sharing many major risk factors, their disease pathophysiology is not fully understood. In this study, we aimed to better distinguish common vs.
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- Human brain behavior differences are linked to brain size and organization, which develop slowly in humans compared to other primates, a phenomenon known as neoteny.
- Research tracking neuronal development across various primate species revealed both similarities and unique distinctions in gene regulation, particularly focusing on the transcription factor GATA3.
- Downregulating GATA3 in human neurons sped up the development of action potentials, suggesting that gene regulation differences contribute to the slower maturation process seen in humans.
Article Synopsis
- Researchers currently use broad methods to measure transposable element (TE) RNA expression, which can’t differentiate between TEs that are transcribed from their own promoters and those that come from neighboring genes, affecting our understanding of their functions.
- The new method, called BonaFide-TEseq, allows for accurate examination of bona fide TE expression using existing single-cell RNA sequencing techniques without needing TE-specific enrichment.
- This approach revealed that TEs, particularly short-interspersed nuclear elements (SINEs), show specific expression patterns in mouse hippocampus and respond to stimuli in ways that relate to learning and memory.