Discovery of Gene Fusions in Driver-Negative Cancer Samples From the National Cancer Institute-Molecular Analysis for Therapy Choice Screening Cohort.

Purpose: The National Cancer Institute-Molecular Analysis for Therapy Choice (NCI-MATCH) trial was implemented to identify actionable genetic alterations across cancer types and enroll patients accordingly onto treatment arms, irrespective of tumor histology. Using multiplex polymerase chain reaction (PCR) next-generation sequencing, NCI-MATCH genotyped 5,540 patients, discovering gene fusions in 202/5,540 tumors (3.65%).

Impact of the Charlson Comorbidity Index on Delirium Outcomes.

Introduction Delirium is a significant inpatient healthcare challenge and has a greater incidence among older adults with adverse healthcare outcomes. Yet there are limited established models for risk stratification. The objective is to determine the effectiveness of implementing the Charlson comorbidity index (CCI) score, which is calculated based on the assigned weight for various disease conditions, and to analyze the healthcare outcomes in older hospitalized adults with delirium.

Expert group recommendation on inhaled mucoactive drugs in pediatric respiratory diseases: an Indian perspective.

Background: Currently, there are no guidelines or consensus statements about the usage of inhaled mucoactive drugs in pediatric respiratory disease conditions from an Indian perspective.

Objective: To develop a practical consensus document to help pediatricians in clinical decision-making when choosing an appropriate mucoactive drug for the management of specific respiratory disease conditions.

Methods: A committee of nine experts with significant experience in pediatric respiratory disease conditions and a microbiological expert constituted the panel.

Metal Ions and their Effects on Antimicrobial Resistance Development in Wastewater.

Antimicrobial resistance (AMR) is a global health challenge and there is increasing recognition of the role of the environment, particularly wastewater, in the development and spread of AMR. Although trace metals are common contaminants in wastewater, the quantitative effects of trace metals on AMR in wastewater settings remain understudied. We experimentally determined the interactions between common antibiotic residues and metal ions found in wastewater and investigated their effects on the development of antibiotic resistance in over time.

Tobacco cessation effects on oral health by group and individualized motivational therapy in 12 to 18 years old boys - A randomized controlled study.

Background/introduction: Adolescents are the most vulnerable population to initiate tobacco use. It is now well established that most of the adult users of tobacco start tobacco use in their childhood or adolescence.

Aim: The purpose of this study is to compare and evaluate the Group Motivational Therapy (GMT) and Individualised Motivational therapy (IMT) for tobacco cessation in adolescents.

Lipid-polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives.

Lipid-polymer hybrid nanoparticles (LPHNPs) are next-generation core-shell nanostructures, conceptually derived from both liposome and polymeric nanoparticles (NPs), where a polymer core remains enveloped by a lipid layer. Although they have garnered significant interest, they remain not yet widely exploited or ubiquitous. Recently, a fundamental transformation has occurred in the preparation of LPHNPs, characterized by a transition from a two-step to a one-step strategy, involving synchronous self-assembly of polymers and lipids.

Effect of Short-term Consumption of Amul Probiotic Yogurt Containing La5 and Lactis Bb12 on Salivary mutans Count in High Caries Risk Individuals.

Aim: This study aims to study the effect of short-term consumption of probiotic yogurt containing La5 and lactis Bb12 on salivary mutans count in high caries risk individuals.

Materials And Methods: A double-blind randomized control trial was conducted, and 70 high caries risk individuals with a salivary count of more than 10 CFU/ml of saliva were followed for 4 weeks. Participants ingested 100 g yogurt containing La5 and lactis Bb12 or yogurt without the two probiotic bacteria once daily at the end of meals for initial 2 weeks.

Endoscopic ultrasonography in pediatric patients--Experience from a tertiary care center in India.

Background And Aims: Although endoscopic ultrasound (EUS) is used in the management of various gastrointestinal (GI) diseases in adults, data on its role in children is limited. This study evaluated the indications, safety, and impact of EUS in children.

Methods: Records of children (<18 years age) who underwent EUS between January 2006 and September 2014 were reviewed retrospectively and analyzed.

An unusual case of solid appendicular mass in a young female.

Endometriosis should be entertained as part of differential diagnosis in females in child-bearing age group when there is an incidental finding of solid neoplasm on imaging. It helps to guide physicians for appropriate management. It is important to emphasize that no radiological or imaging finding is pathognomonic for endometriosis.