Synopsis of recent research by authors named "Kalyan Dewan"
- Kalyan Dewan's recent research focuses on understanding the immune mechanisms involved in neonatal protection against pathogens, specifically highlighting how the pertussis toxin (PTx) affects the neonatal immune system's ability to clear infections like Bordetella pertussis.
- His work also investigates the immune responses in various contexts, including chronic otitis media (COM) and the unique immune protection offered by the middle ear compared to the respiratory tract, emphasizing the need for novel animal models to study these conditions.
- Additionally, Dewan explores the evolutionary aspects of Bordetella pathogens, particularly their adaptations for evading host immunity and the implications of vaccine-driven evolution on pertussis strains, indicating significant shifts in how these pathogens interact with their hosts.
