Publications by Kalvin Connor | LitMetric

Publications by authors named "Kalvin Connor"

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Cardiovascular Evaluation of Etrasimod, a Selective Sphingosine 1-phosphate Receptor Modulator, in Healthy Adults: Results of a Randomized, Thorough QT/QTc Study.

Borje Darpo Kalvin Connor Christopher H Cabell John S Grundy

Clin Pharmacol Drug Dev

April 2024

Article Synopsis

Etrasimod is a potential oral medication for treating immune-related inflammatory disorders, being tested for its effects on heart electrical activity, specifically the QT interval.
The study involved healthy adults receiving either etrasimod in varying doses or placebos, with the main focus on its impact on the QT interval measured through electrocardiograms.
Results showed that etrasimod's impact on the QTc interval was minimal, remaining below 10 milliseconds, and it only caused slight, temporary decreases in heart rate without any significant heart block issues.

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