A New Species of Chigger (Acari: Trombiculidae) from Indonesia and Current Differentiation of Trombicula Berlese, 1905 Sensu Stricto Group.

Background: Two new species of chiggers in the two genera (Chiroptella Vercammen-Grandjean, 1960 and Rudnicula Vercammen-Grandjean, 1964) have been described in Indonesia since 2020. The checklist of all known bat-infesting chiggers has also been compiled for Indonesia. It summarizes 16 species in 9 genera of chiggers parasitizing 12 bat species belonging to 5 families collected on 8 Indonesian islands.

Two new species of Cunaxa (Acari, Prostigmata, Cunaxidae) from South-East Asia with a world key to the genus.

Two new mite species of the family Cunaxidae (Acari, Prostigmata)-Cunaxa asiatica sp. nov. and C.

Bat-Infesting Chiggers (Trombiculidae) in Indonesia: Current Review, Distribution, and Hosts with Three New Records and their Morphometric Data.

Purpose: Even though the taxonomy of bat-infesting chiggers has been studied extensively, information about the distribution and morphological variability of many species is still lacking. In fact, the only available distribution records for several species are their type localities. The purpose of this paper is to broaden the knowledge of the Indonesian group.

Targeting HIF-activated collagen prolyl 4-hydroxylase expression disrupts collagen deposition and blocks primary and metastatic uveal melanoma growth.

Uveal melanoma (UM) is the most prevalent primary intraocular malignancy in adults, and patients that develop metastases (~50%) survive <1 year, highlighting the urgent need for new therapies. TCGA has recently revealed that a hypoxia gene signature is associated with poor UM patient prognosis. Here we show that expression of hypoxia-regulated collagen prolyl-4-hydroxylase genes P4HA1 and P4HA2 is significantly upregulated in UM patients with metastatic disease and correlates with poor prognosis, suggesting these enzymes might be key tumor drivers.

A new species of Chiroptella Vercammen-Grandjean, 1960 (Acari: Trombiculidae) from diadem leaf-nosed bat Hipposideros diadema (Geoffroy) (Chiroptera: Hipposideridae) in Bali Island (Indonesia) with distribution records, hosts, and a key to the species of the genus.

A new chigger mite Chiroptella baliensis n. sp. is described based on material from the diadem leaf-nosed bat Hipposideros diadema (Geoffroy) (Hipposideridae) in Bali Island (Lesser Sunda Islands, East Indonesia).

Rudnicula goffi n. sp. (Acariformes: Trombiculidae) from the diadem leaf-nosed bat Hipposideros diadema (Geoffroy) (Chiroptera: Hipposideridae) on Bali, Indonesia.

A new species of chigger mite, Rudnicula goffi n. sp., is described from the diadem leaf-nosed bat Hipposideros diadema (Geoffroy) (Hipposideridae) caught in the Goa Peteng Cave on Bali (Indonesia).

A new genus of Pulaeini (Acari: Prostigmata: Cunaxidae) from South-East Asia.

A new genus Lepidocunaxoides gen. nov., with the type species Lepidocunaxoides robustus sp.

Correction: EZH2 targeting reduces medulloblastoma growth through epigenetic reactivation of the BAI1/p53 tumor suppressor pathway.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

EZH2 targeting reduces medulloblastoma growth through epigenetic reactivation of the BAI1/p53 tumor suppressor pathway.

Medulloblastoma (MB) is a malignant pediatric brain tumor for which new therapies are urgently needed. We demonstrate that treatment with EPZ-6438 (Tazemetostat), an enhancer of zeste homolog 2 (EZH2) inhibitor approved for clinical trials, blocks MB cell growth in vitro and in vivo, and prolongs survival in orthotopic xenograft models. We show that the therapeutic effect is dependent on epigenetic reactivation of adhesion G-protein-coupled receptor B1 (BAI1/ADGRB1), a tumor suppressor that controls p53 stability by blocking Mdm2.

A description of the male of Geckobiella donnae Paredes-León, Klompen et Pérez, 2012 (Acari: Pterygosomatidae) from captive iguanas in Honduras.

Mites of the family Pterygosomatidae are usually infesting lizards, geckos and iguanas. In this family, the genus Geckobiella Hirst, 1917 comprises 12 species including Geckobiella donnae Paredes-León, Klompen et Pérez, 2012. We collected 48 mites of G.

Arylsulfonamide 64B Inhibits Hypoxia/HIF-Induced Expression of c-Met and CXCR4 and Reduces Primary Tumor Growth and Metastasis of Uveal Melanoma.

Purpose: Uveal melanoma (UM) is the most prevalent and lethal intraocular malignancy in adults. Here, we examined the importance of hypoxia in UM growth and tested the antitumor effects of arylsulfonamide 64B, an inhibitor of the hypoxia-induced factor (HIF) pathway in animal models of UM and investigated the related mechanisms.

Experimental Design: UM cells were implanted in the uvea of mice eyes and mice systemically treated with 64B.

The chiggers (Acari: Trombiculidae) on wild birds in Honduras.

The chiggers (Acari: Trombiculidae) Blankaartia sinnamaryi (Floch et Fauran, 1956), Parasecia soucouyanti (Brennan et Yunker, 1966), Eutrombicula lipovskyana (Wolfenbarger, 1952) and Neoschoengastia dalmati Brennan, 1951 were found in Honduras on a total of twelve bird species. Parasecia soucouyanti was recorded parasitising birds for the first time. All these mites are here reported from Honduras for the first time.

Two new species of the family Cunaxidae (Acari: Prostigmata) from Madagascar.

Two new mite species from Madagascar, based on female specimens, viz. Armascirus skvarlai sp. nov.

A novel small-molecule arylsulfonamide causes energetic stress and suppresses breast and lung tumor growth and metastasis.

Neoplastic cells display reprogrammed metabolism due to the heightened energetic demands and the need for biomass synthesis of a growing tumor. Targeting metabolic vulnerabilities is thus an important goal for cancer therapy. Here, we describe a novel small-molecule arylsulfonamide (N-cyclobutyl-N-((2,2-dimethyl-2-pyrano[3,2-]pyridin-6-yl)methyl)-3,4-dimethoxybenzenesulfonamide) that exerts potent cytotoxicity and energetic stress on tumor cells while largely sparing non-cancerous human cells.

Purifying Properly Folded Cysteine-rich, Zinc Finger Containing Recombinant Proteins for Structural Drug Targeting Studies: the CH1 Domain of p300 as a Case Example.

The transcription factor Hypoxia-Inducible Factor (HIF) complexes with the coactivator p300, activating the hypoxia response pathway and allowing tumors to grow. The CH1 and CAD domains of each respective protein form the interface between p300 and HIF. Small molecule compounds are in development that target and inhibit HIF/p300 complex formation, with the goal of reducing tumor growth.

Design and synthesis of benzopyran-based inhibitors of the hypoxia-inducible factor-1 pathway with improved water solubility.

While progress has been made in treating cancer, cytotoxic chemotherapeutic agents are still the most widely used drugs and are associated with severe side-effects. Drugs that target unique molecular signalling pathways are needed for treating cancer with low or no intrinsic toxicity to normal cells. Our goal is to target hypoxic tumours and specifically the hypoxia inducible factor (HIF) pathway for the development of new cancer therapies.

A role for activated Cdc42 in glioblastoma multiforme invasion.

Cdc42 is a Rho-GTPase which plays a major role in regulating cell polarity and migration by specifying the localization of filopodia. However, the role of Cdc42 in GBM invasion has not been thoroughly investigated. We generated stable doxycycline-inducible clones expressing wild type (WT)-, constitutively active (CA)-, and dominant negative (DN)-Cdc42 in three different human glioma cell lines.

Two new species and new records of chiggers (Acari: Leeuwenhoekiidae, Trombiculidae) from birds in Vietnam.

A total of 12 chigger species (Acariformes: Trombiculidae) occurred on 7 bird species in Vietnam. Two new species, namely Neoschoengastia vietnamensis sp. nov.

First detections of Rickettsia helvetica and R. monacensis in ectoparasitic mites (Laelapidae and Trombiculidae) infesting rodents in south-western Slovakia.

Information on circulation of rickettsiae between small mammals and their ectoparasitic mites is scarce. In this study, we investigated infestation rates of rodents with mites in some areas of SW Slovakia and the role of mites as possible vectors of pathogenic rickettsiae. A total of 615 rodents of five species were caught during 2010-2012.

Two new species of the genus Armascirus (Acari: Prostigmata: Cunaxidae) from India and Vietnam, with a description of the preimaginal stage of Armascirus fendai.

Two new mite species from India and Vietnam, viz. Armascirus denheyeri sp. nov.

Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex.

Mitochondrial pyruvate dehydrogenase complex (PDC) is crucial for glucose homeostasis in mammalian cells. The current understanding of PDC regulation involves inhibitory serine phosphorylation of pyruvate dehydrogenase (PDH) by PDH kinase (PDK), whereas dephosphorylation of PDH by PDH phosphatase (PDP) activates PDC. Here, we report that lysine acetylation of PDHA1 and PDP1 is common in epidermal growth factor (EGF)-stimulated cells and diverse human cancer cells.

Hypoxia inducible factor pathway inhibitors as anticancer therapeutics.

Hypoxia is a significant feature of solid tumor cancers. Hypoxia leads to a more malignant phenotype that is resistant to chemotherapy and radiation, is more invasive and has greater metastatic potential. Hypoxia activates the hypoxia inducible factor (HIF) pathway, which mediates the biological effects of hypoxia in tissues.

Three new species of Oppioidea (Acari: Oribatida) from India.

Three new oribatid mite species of the superfamily Oppioidea--Cycloppia asetosa sp. nov., C.