Association Between the Immune Checkpoint Inhibitor Durvalumab and Myasthenia Gravis: A Comprehensive Review.

Immune checkpoint inhibitors (ICIs), including Imfinzi (durvalumab), have revolutionized cancer treatment by stimulating the body's immune system to target cancerous cells. Although pharmaceuticals offer therapeutic benefits, several drugs have been associated with immune-related adverse events (irAEs), including the uncommon but serious condition known as myasthenia gravis (MG). This review synthesizes data from pertinent research to offer a thorough evaluation of the literature on the underlying mechanisms, clinical manifestations, and therapeutic approaches for durvalumab-induced MG.

Clinical Profile and Outcomes of Patients With Hypercalcemia in an Indian Tertiary Care Center.

Hypercalcemia is a complex medical condition characterized by elevated levels of serum calcium (>10.5 mg/dL) in the bloodstream, often arising from various underlying etiologies. This condition presents a significant clinical challenge due to its diverse clinical manifestations and potential for serious complications.

Hyponatremia and Outcome: Is Severity More Important Than Etiology?

Background And Objective: Hyponatremia is the most common electrolyte abnormality encountered in a hospital setting, and the data regarding the contribution of hyponatremia to overall mortality are conflicting. The study objective was to determine patients' clinical profiles and outcomes with hyponatremia.

Methods:  This prospective cross-sectional study was conducted at Dayanand Medical College and Hospital, Ludhiana, and included 375 adult patients aged more than 18 years with a confirmed diagnosis of hyponatremia.

Impact of Aspirin Use on Outcomes in Patients With Hepatocellular Cancer: A Nationwide Analysis.

Background: Despite the use of new immunotherapies, hepatocellular carcinoma (HCC) has a poor survival rate. Through multiple molecular mechanisms, aspirin (ASA) has demonstrated a reduced incidence of HCC, however, the impact of long-term ASA use on in-hospital outcomes has not been studied.

Methods: We queried the National Inpatient Sample (NIS) database from 2016 to 2020 to identify patients with HCC.

Prevalence and risk factors of asthma and wheeze in school-going children in Lucknow, North India.

Objective: To assess the prevalence of asthma and wheeze and factors associated with it in children aged 6-7 and 13-14 years.

Method: School based, prospective survey using self/parental reporting of occurrence of asthma or wheeze on pre-designed questionnaire.

Results: Out of 112 schools, 17 and 15 schools were randomly selected for recruitment of subjects in age group 6-7 and 13-14 years, respectively.

Depression as a communicable disorder.

'Communicable disorder' can be defined as a disorder capable of being transmitted in the form of negative emotion(s) from living or non-living being(s) to susceptible host. Thus, communicable disorder is transmitted from the source or reservoir of disorder to the susceptible host. The source of disorder can be defined as the living or non-living being from which the disorder in the form of negative emotion(s) gets transmitted to the susceptible host.

Nutraceutical--definition and introduction.

Dr Stephen DeFelice coined the term "Nutraceutical" from "Nutrition" and "Pharmaceutical" in 1989. The term nutraceutical is being commonly used in marketing but has no regulatory definition. An attempt to redefine nutraceuticals and functional foods is made in this article.

Can a change in the name of depression result in its reduced negativity?

The National Institute of Mental Health Epidemiologic Catchment Area (ECA) study, an extensive community survey, reported that the 6-month prevalence rates for mood disorders were 6% (the lifetime rate was 8.3%) while only 31% of depressed adults sought treatment. The reluctance of patients for treatment of depression can be attributed to some extent to the negativity associated with it at social level.