Circulating Tumor DNA Assessment for Treatment Monitoring Adds Value to PSA in Metastatic Castration-Resistant Prostate Cancer.

Purpose: Enzalutamide after abiraterone progression is commonly used in metastatic castration-resistant prostate cancer despite a low rate of clinical benefit. Analyzing IMbassador250, a phase III trial assessing enzalutamide with or without atezolizumab after abiraterone, we hypothesized that baseline and early changes in circulating tumor DNA (ctDNA) tumor fraction (TF) may identify patients more likely to exhibit survival benefit from enzalutamide.

Experimental Design: ctDNA was quantified from plasma samples using a tissue-agnostic assay without buffy coat sequencing.

3D-Printable Sustainable Bioplastics from Gluten and Keratin.

Bioplastic films comprising both plant- and animal-derived proteins have the potential to integrate the optimal characteristics inherent to the specific domain, which offers enormous potential to develop polymer alternatives to petroleum-based plastic. Herein, we present a facile strategy to develop hybrid films comprised of both wheat gluten and wool keratin proteins for the first time, employing a ruthenium-based photocrosslinking strategy. This approach addresses the demand for sustainable materials, reducing the environmental impact by using proteins from renewable and biodegradable sources.

Waste to energy: Trending key challenges and current technologies in waste plastic management.

Due to the 'forever' degrading nature of plastic waste, plastic waste management is often complicated. The applications of plastic are ubiquitous and inevitable in many scenarios. Current global waste plastics production is ca.

First-Line Ipatasertib, Atezolizumab, and Taxane Triplet for Metastatic Triple-Negative Breast Cancer: Clinical and Biomarker Results.

Purpose: To evaluate a triplet regimen combining immune checkpoint blockade, AKT pathway inhibition, and (nab-) paclitaxel as first-line therapy for locally advanced/metastatic triple-negative breast cancer (mTNBC).

Patients And Methods: The single-arm CO40151 phase Ib study (NCT03800836), the single-arm signal-seeking cohort of IPATunity130 (NCT03337724), and the randomized phase III IPATunity170 trial (NCT04177108) enrolled patients with previously untreated mTNBC. Triplet therapy comprised intravenous atezolizumab 840 mg (days 1 and 15), oral ipatasertib 400 mg/day (days 1-21), and intravenous paclitaxel 80 mg/m2 (or nab-paclitaxel 100 mg/m2; days 1, 8, and 15) every 28 days.

Bone Graft Substitutes-What Are My Options?

We examine the range of available bone graft substitutes often used in nonunion and malunion surgery of the upper extremity. Synthetic materials such as calcium sulfate, beta-calcium phosphate ceramics, hydroxyapatite, bioactive glass, and 3D printed materials are discussed. We delve into the advantages, disadvantages, and clinical applications for each, considering factors such as biocompatibility, osteoconductivity, mechanical strength, and resorption rates.

Wood biochar enhances methanogenesis in the anaerobic digestion of chicken manure under ammonia inhibition conditions.

The process of breaking down chicken manure through anaerobic digestion is an effective waste management technology. However, chicken manure can be a challenging feedstock, causing ammonia stress and digester instability. This study examined the impacts of adding wood biochar and acid-alkali-treated wood biochar to anaerobically digest chicken manure under conditions of ammonia inhibition.

Is There a Critical Dorsal Lunate Facet Size in Distal Radius Fractures That Leads to Dorsal Carpal Subluxation? A Biomechanical Study of the Dorsal Critical Corner.

Purpose: Intra-articular distal radius fractures are common and can be associated with carpal instability. Failure to address articular fragments linked to maintaining carpal stability can lead to radiocarpal subluxation or dislocation. The purpose of this study was to evaluate the size of a dorsal osteotomy in the dorsal/volar plane of the lunate facet that leads to dorsal carpal subluxation.

A study of biochar physiochemistry and particle size distribution influencing the properties of water-based slurry fuels.

Biochar-based slurry is a fossil-free-liquid fuel derived from a renewable source, biomass. This study aims to examine the properties of this fuel as an alternative to coal-water slurries. The slurries were produced by suspending 40 wt% biochar in a solution made of water and a surfactant.

Synthesis and application of manganese-doped zinc oxide as a potential adsorbent for removal of Congo red dye from wastewater.

Synthetic dyes are considered toxic compounds and as such are not easily removed by conventional water treatment processes. This study demonstrated the synthesis of pure and manganese- (Mn), silver- (Ag), and iron- (Fe) doped zinc oxide (ZnO) nanoparticles via the wet chemical route. In particular, it investigated the batch adsorption studies and physiochemical properties of synthesized pure and doped ZnO materials for removing toxic congo red (CR) dye.

Failure of humeral shaft fixation: construct characteristics.

Purpose: Fixation failure following open reduction and internal fixation (ORIF) of humeral shaft fractures can be a challenging complication. We aimed to identify the modes of failure and characteristics of failed fixation constructs.

Methods: We queried our institutional database for patients > 18 years old with fixation failure after ORIF with single plate and screw constructs of humeral shaft fractures from 2006 to 2017.

Antegrade Fixation of Distal Metaphyseal Ulnar Shortening Osteotomy.

The ulnar shortening osteotomy (USO) is a common procedure used to treat ulnar impaction syndrome secondary to static or dynamic ulnar-positive variance. There are many described techniques for the USO. The distal metaphyseal ulnar shortening osteotomy (DMUSO) with retrograde cannulated screw fixation was described to reduce complications seen with other techniques.

Green synthesis of zinc oxide nanoparticles using lychee peel and its application in anti-bacterial properties and CR dye removal from wastewater.

In nanoscience and nanobiotechnology, using plant extracts in synthesizing metal nanoparticles (NPs) has recently come to light as an exciting opportunity with several benefits over traditional physicochemical methods. In the present work, zinc oxide (ZnO) based nanoparticles (NPs) were synthesized by green chemistry route using lychee peel extract to capture hazardous congo red dye from wastewater and illustrate their antimicrobial behavior. The X-Ray Diffraction (XRD) spectra confirm the wurtzite crystal structure, and Fourier Transform Infrared (FTIR) spectra confirm the functional group in ZnO, which is suitable for dye adsorption.

Is Hand Surgery in the Procedure Room Setting Associated With Increased Surgical Site Infection? A Cohort Study of 2,717 Patients in the Veterans Affairs Population.

Purpose: Procedure rooms (PRs) are increasingly used for hand surgeries, but few studies have directly compared surgical site infection (SSI) rates between the PR and operating room. We tested the hypothesis that procedure setting is not associated with an increased SSI incidence in the VA population.

Methods: We identified carpal tunnel, trigger finger, and first dorsal compartment releases performed at our VA institution from 1999 to 2021 of which 717 were performed in the main operating room and 2,000 were performed in the PR.

Development of a ZnOS+C Composite as a Potential Adsorbent for the Effective Removal of Fast Green Dye from Real Wastewater.

Wastewater treatment is becoming increasingly important due to the potential shortage of pure drinking water in many parts of the world. Adsorption offers a potential technique for the uptake of contaminants and wastewater purification. In the last two decades, several efforts have been made to remove fast green (FG) dye from wastewater via different adsorbent materials.

What Program Characteristics Are Associated with Resident Racial Diversity in Orthopaedic Surgery? An Analysis of Association of American Medical Colleges Data.

Unlabelled: In orthopaedic surgery, there are fewer Black or African American (4%) and Hispanic or Latino (4%) residents compared with general surgery, internal medicine, family medicine, and pediatrics (5%-7% Black residents and 7%-9% Hispanic/Latino residents, respectively). There are also fewer underrepresented in medicine minority (URiM) faculty in orthopaedic surgery (6.1%) compared with general surgery (8.

Production of H and CNM from biogas decomposition using biosolids-derived biochar and the application of the CNM-coated biochar for PFAS adsorption.

Anaerobic digestion is a popular unit operation in wastewater treatment to degrade organic contaminants, thereby generating biogas (methane-rich gas stream). Catalytic decomposition of the biogas could be a promising upcycling approach to produce renewable hydrogen and sequester carbon in the form of carbon nanomaterials (CNMs). Biosolids are solid waste generated during the wastewater treatment process, which can be valorised to biochar via pyrolysis.

Helping Surgeons' Hands: A Biomechanical Evaluation of Ergonomic Instruments.

Purpose: "Ergonomic" is a common descriptor for a desk or computer workspace but is a term rarely used to describe a surgical instrument. Instead, surgeons spend many hours in inconvenient positions, often using instruments that are not ergonomic. Improving the ergonomics of surgical instruments may decrease the required force for simple tasks and allow for more efficient surgery.

Techno-economic analysis of ionic liquid pre-treatment integrated pyrolysis of biomass for co-production of furfural and levoglucosenone.

In the current work, a techno-economic analysis of pyrolysis of choline glycinate pre-treated biomass has been presented for the co-production of furfural and levoglucosenone along with hemicellulose, lignin and biochar as other byproducts. The mass balance suggested that the 1800 kg/h dry sugarcane straw biorefinery plant could produce about 260 kg/h furfural and 65 kg/h levoglucosenone. The minimum selling price of furfural and levoglucosenone were also estimated and the values were 1640 and 3590 AU$/tonne at 11.

Distal Metaphyseal Ulnar Shortening Osteotomy Fixation: A Biomechanical Analysis.

Purpose: Ulnar shortening osteotomy can be used to treat ulnar impaction syndrome and other causes of ulnar wrist pain. Distal metaphyseal ulnar shortening osteotomy (DMUSO) is one technique that has been proposed to reduce the complications seen with a diaphyseal USO or a wafer resection. However, to our knowledge, the optimal fixation construct for DMUSO has not been studied.

The co-application of biochar with bioremediation for the removal of petroleum hydrocarbons from contaminated soil.

Soil pollution from petroleum hydrocarbon is a global environmental problem that could contribute to the non-actualisation of the United Nations Sustainable Development Goals. Several techniques have been used to remediate petroleum hydrocarbon-contaminated soils; however, there are technical and economical limitations to existing methods. As such, the development of new approaches and the improvement of existing techniques are imperative.

Radiocarpal Fusion: Indications, Technique, and Modifications.

Degenerative disorders of the wrist may affect isolated joints and inhibit normal functions of the wrist secondary to pain and stiffness. These processes that affect only the radiocarpal joint may be secondary to posttraumatic osteoarthritis, primary osteoarthritis, or rheumatoid arthritis. Radiocarpal wrist arthrodesis may help preserve some of the native wrist kinematics while alleviating pain and improving the range of motion.