Publications by authors named "Kalpesh Thakkar"
Background Aims: Esophageal eosinophilia (EE) can be caused by gastroesophageal reflux disease (GERD), proton-pump inhibitor-responsive EE (PPI-REE) or eosinophilic esophagitis (EoE). This study quantified protein expression and S-nitrosylation (SNO) post-translational modifications in EE to elucidate potential disease biomarkers.
Methods: Proximal and distal esophageal (DE) biopsy proteins in patients with EE and in controls were assayed for protein content and fluorescence-labeled with and without ascorbate treatment.
Disaccharidase activity in children undergoing esophagogastroduodenoscopy: A systematic review.
World J Gastrointest Pharmacol Ther
May 2016
Aim: To investigate the utility of intestinal disaccharide analysis during esophagogastroduodenoscopy (EGD) in children, we performed a systematic review of studies examining disaccharide activity.
Methods: All full-length articles published in English during 1966-2014 were included if: (1) participants had small intestinal biopsy evaluation of disaccharide activity; (2) levels of lactase, sucrase, maltase or palatinase were reported; and (3) age of participants was under 18 years.
Results: Thirty articles examining 34753 disaccharide assays fulfilled the specific search, inclusion, and exclusion criteria.
Background And Aims: Currently, there are no quality measures specific to children undergoing GI endoscopy. We aimed to determine the baseline quality of pediatric colonoscopy by using the Pediatric Endoscopy Database System-Clinical Outcomes Research Initiative (PEDS-CORI), a central registry.
Methods: We conducted prospective data collection by using a standard computerized report generator and central registry (PEDS-CORI) to examine key quality indicators from 14 pediatric centers between January 2000 and December 2011.
Outcomes of children after esophagogastroduodenoscopy for chronic abdominal pain.
Clin Gastroenterol Hepatol
June 2014
Background & Aims: Chronic abdominal pain is the most common indication for esophagogastroduodenoscopy (EGD) in children. However, little is known about the accuracy of EGD-based diagnosis or the outcomes of the patients who undergo this procedure. We examined the diagnostic yield of EGD and short-term outcomes of children who underwent this procedure for chronic abdominal pain.
View Article and Find Full Text PDFPurpose Of Review: Colorectal polyps are a common cause of gastrointestinal bleeding in children. This review updates the information on colorectal polyps and summarizes the recent advances in genetics, diagnosis, and treatment of polyps in the large intestine.
Recent Findings: A review of recent literature regarding colorectal polyps demonstrates an estimated detected prevalence of 6.
Background: The available data regarding the prevalence, types, and clinical determinants of colonic polyps in children is limited.
Aims: We aimed to estimate the prevalence of colorectal polyps in a large cohort of children.
Methods: We conducted a cross-sectional study to determine the presence, number, and location of colorectal polyps reported in all children (0-20 years) who underwent colonoscopy at 14 pediatric facilities between January 2000 and December 2007 recorded in Pediatric Endoscopy Database System Clinical Outcomes Research Initiative (PEDS-CORI).
Background: Endoscopy is performed frequently in children with chronic abdominal pain (CAP), but its impact on clinical management is unclear.
Aims: We aimed to examine the frequency of changes in immediate medical management resulting from endoscopy with biopsy evaluating CAP in children.
Methods: We conducted a prospective cross-sectional study to assess the frequency and determinants of management change in children who underwent endoscopy for evaluation of chronic abdominal pain.
Context: The relationship between gastroesophageal reflux disease (GERD) and asthma in children has been investigated; however, the nature of the association (if any) between these 2 conditions is unclear.
Objective: We performed a systematic review of the literature to examine the association between GERD and asthma in children.
Methods: A search of the medical literature was conducted by using PubMed and Embase (1966 through December 2008).
Objectives: Endoscopy is commonly performed in the diagnosis of children with inflammatory bowel disease (IBD). The utility of repeat endoscopy for the management of pediatric IBD has not been subject to investigation. The frequency and determinants of changes in medical management resulting from endoscopy are unknown.
View Article and Find Full Text PDFBackground: Available estimates of the incidence and type of complications during pediatric EGD are inconsistent.
Objective: To determine the frequency and the determinants of immediate complications during EGD in children.
Design: We conducted a cross-sectional database study.
Background: We performed a systematic review to examine the diagnostic yield (endoscopic and histologic) of esophagogastroduodenoscopy (EGD) for the evaluation of abdominal pain of unclear etiology in children. We also examined the effect of EGD on change in treatment, quality of life, change in abdominal pain, and cost-effectiveness.
Methods: All full-length articles published in English during 1966-2005 were included if: (a) participants had abdominal pain without known underlying gastrointestinal disease, (b) participants underwent EGD primarily for the evaluation of abdominal pain, (c) findings of the EGD were reported, (d) participants were under 18 yr, and (e) sample size greater than 50.
Background: Diarrhea is a common problem in critically ill patients. Our patients are fed a high-carbohydrate enteral formula. We hypothesized that diarrhea in our patients may be related to the osmotic effects of unabsorbed carbohydrate in the small intestine and colon.
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