Folia Med (Plovdiv)
December 2018
Background: The suggested dose of ivermectin is 300 μG/kg/day for onchocerciasis but it has low water solubility and poor oral bioavailability.
Aim: To prepare and evaluate a solid lipid-based self-emulsifying drug delivery system of ivermectin.
Materials And Methods: Based on supersaturated solubility study, oil, surfactant, and co-surfactant were selected.