Temperature-dependent in Situ Gel of Clotrimazole: an Experimental Study.

Background: The in-situ gel-forming polymeric formulations offer sustained and prolonged action in comparison to conventional drug delivery systems.

Aim: To formulate and evaluate in situ vaginal gel of clotrimazole.

Materials And Methods: Poloxamer 407 (20%) was slowly added to freezing water (5°C) with constant stirring.

Formulation Studies of Solid Self-Emulsifying Drug Delivery System of Ivermectin.

Background: The suggested dose of ivermectin is 300 μG/kg/day for onchocerciasis but it has low water solubility and poor oral bioavailability.

Aim: To prepare and evaluate a solid lipid-based self-emulsifying drug delivery system of ivermectin.

Materials And Methods: Based on supersaturated solubility study, oil, surfactant, and co-surfactant were selected.

Microemulgel of Voriconazole: an Unfathomable Protection to Counter Fungal Contagiousness.

Background: Fluconazole and ketoconazole both have poor minimum inhibitory concentration than voriconazole. Voriconazole had serious side effects in oral and intravenous doses. It has poor water solubility.

Nuts and Bolts of Oil and Temperature in Topical Preparations of Salicylic Acid.

Background: Traditional formulations of salicylic acid in ointment bases have disadvantages of being greasy and irritant due to free crystals.

Aim: To explore the method for selection of oils and their ratio for topical preparation on the basis of equilibrium solubility study of salicylic acid and to evaluate temperature effect.

Materials And Methods: Scanning and calibration curve of salicylic acid in methanol were developed.

Association of Permeability and Lipid Content of Membrane.

Background: Rat skin and goat cul de sac are mostly used in optimization of formulations as the model of human skin and cul de sac.

Aim: To explore the correlation between lipid content of rat skin and goat cul de sac and permeability.

Materials And Methods: Find out wavelength maximum for Sapat plus malam®, Ciplox eye ointment® and chloramphenicol eye caps and the standard curve was also derived.

Emulsion of Chloramphenicol: an Overwhelming Approach for Ocular Delivery.

Background: Ophthalmic formulations of chloramphenicol have poor bioavailability of chloramphenicol in the ocular cavity.

Aim: The present study aimed at exploring the impact of different oil mixtures in the form of emulsion on the permeability of chloramphenicol after ocular application.

Materials And Methods: Selection of oil mixture and ratio of the components was made by an equilibrium solubility method.

Microemulgel: an overwhelming approach to improve therapeutic action of drug moiety.

As compared to gel and other topical preparations microemulgel has been prepared by screening of oils, emulsifier, and co-emulsifier on bases of solubility of an API in it. An API has high solubility and oil may also have more or less pharmacological property, so it may assist the therapeutic action of API. Due to presence of oil portion, it leads to more penetration of API in the skin.